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The Role of Intravenous Selexipag in Managing PAH and Bridging Gaps in Oral Treatment: A Narrative Review.
Ther Clin Risk Manag
January 2025
Departments of Medicine and Cardiology, Westchester Medical Center and New York Medical College, Valhalla, NY, USA.
Pulmonary arterial hypertension (PAH) is a rare and potentially fatal condition characterized by progressive increases in blood pressure in the arteries of the lungs. Oral selexipag, approved by the Food and Drug Administration (FDA) in 2015 for the treatment of PAH, targets prostacyclin receptors on pulmonary arterial vascular smooth muscle and endothelial cells to improve blood flow through the lungs and reduce pulmonary vascular resistance. Oral selexipag is effective, but may be discontinued due to factors like side effects, emergency conditions, or inability to take oral medication, potentially leading to severe adverse events, such as rebound pulmonary hypertension and right heart failure.
View Article and Find Full Text PDFSurgical Management of Acute Appendicitis in a Patient with Diagnosed but "Unprepared" Pheochromocytoma: A Case Report.
Sisli Etfal Hastan Tip Bul
December 2024
Department of General Surgery, University of Health Sciences Türkiye, Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Türkiye.
Pheochromocytoma is a rare tumor originating from the adrenal gland, characterized by the secretion of catecholamines. Due to the risk of hypertensive crises associated with catecholamine release, surgical procedures in pheochromocytoma patients are risky. In this case report, laparoscopic appendectomy for acute appendicitis in a patient who has pheochromocytoma will be presented.
View Article and Find Full Text PDFImpact of the COVID-19 pandemic on primary care for hypertension in the UK: a population-based cohort study.
BMJ Open
December 2024
Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Québec, Canada
Objectives: To describe the impact of the COVID-19 pandemic on hypertension diagnosis and management in UK primary care.
Design: Population-based cohort study.
Setting: Over 2000 general practices across the UK contributing to the Clinical Practice Research Datalink.
CROI 2024: The Challenges of Sustained Viral Suppression, Advanced HIV Disease, and Ending the HIV Epidemic Targets.
Top Antivir Med
August 2024
New York Blood Center, New York, New York, USA.
Data on the HIV care cascade demonstrated challenges in achieving Ending the HIV Epidemic (EHE) targets across all 18 EHE focus metropolitan areas, but innovative adherence interventions using point-of-care tenofovir testing and motivational interviewing support care cascade outcomes in Namibia and South Africa, respectively. Data on treatment with long-acting injectable (LAI) antiretroviral therapy (ART) demonstrated high acceptability, retention, and virologic suppression including in groups that were not well represented in clinical trials including persons born female and persons with detectable viral loads. The adjuvanted hepatitis B vaccine appeared to be safe and appeared to be superior to conventional hepatitis B vaccines in persons with HIV (PWH) who were prior nonresponders to the hepatitis B vaccine.
View Article and Find Full Text PDFAcute Large Bowel Obstruction Post Umbilical Hernia Repair Surgery: A Case Report.
Cureus
October 2024
Surgery, Bakersfield Memorial, Bakersfield, USA.
Article Synopsis
- - Large bowel obstruction (LBO) is relatively rare, often caused by colorectal adenocarcinoma, and it typically presents with symptoms like abdominal pain, constipation, and nausea; a CT scan is crucial for diagnosis.
- - A case study of a 41-year-old male showed severe LBO after a hernia repair, requiring emergency surgery due to findings of a blocked sigmoid colon and complications like pneumatosis.
- - Diverticulitis, which is increasingly affecting younger individuals, can lead to bowel obstructions and serious complications; educating all patients about risk factors, including diet and surgical history, is important.
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