The purpose of this study was to observe the effectiveness of lidocaine in suppressing cough which is a logical extension of its established use in bronchoscopy. Nebulized lidocaine, preceded by standard nebulized albuterol inhalation driven by oxygen was given to suppress cough in a selected group of patients with intractable cough severe enough to disrupt daily life activities, especially sleep. Patients included those with asthma, reactive airways disease, and chronic obstructive pulmonary disease (COPD). In these selected patients, nebulized lidocaine was very effective in suppressing cough, and thus buying time for more definitive therapies to work. This observation merits further study and confirmation for the benefit of patients.(Am J Emerg Med 2001;19:206-207.
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http://dx.doi.org/10.1053/ajem.2001.21724 | DOI Listing |
Am Fam Physician
January 2025
Duke University School of Medicine, Durham, N.C.
Gastroesophageal reflux is a common physiologic event in infants in which gastric contents pass from the stomach into the esophagus. Gastroesophageal reflux may be asymptomatic or cause regurgitation or "spit up." This occurs daily in approximately 40% of infants.
View Article and Find Full Text PDFIndian J Thorac Cardiovasc Surg
February 2025
Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka India.
Autoimmune hemolytic anemia (AIHA) secondary to mediastinal teratoma is a very rare clinical entity. They can be primary or secondary to any infections, malignancy, etc. Yet at times, there could be a delay in the diagnosis.
View Article and Find Full Text PDFJ Clin Med
January 2025
Corewell Health, Grand Rapids, MI 49503, USA.
Chronic cough is a distressing and prevalent symptom in interstitial lung disease (ILD), significantly impairing quality of life (QoL) and contributing to disease progression, particularly in idiopathic pulmonary fibrosis (IPF). It is associated with physical discomfort, psychological distress, and social isolation and is often refractory to conventional therapies. The pathophysiology of cough in ILD is complex and multifactorial, involving neural hypersensitivity, structural lung changes, inflammatory processes, and comorbid conditions such as gastroesophageal reflux disease (GERD).
View Article and Find Full Text PDFJ Ethnopharmacol
January 2025
State Key Laboratory of Traditional Chinese Medicine Syndrome, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China; Chinese Medicine Guangdong Laboratory, Guangdong Hengqin, 519000, China. Electronic address:
Ethnopharmacological Relevance: In traditional Chinese medicine, the radices of Glycyrrhiza uralensis Fisch, known as liquorice, have been used for relieving cough, alleviating pain and harmonizing the actions of all medicinals in a formula. Glycyrrhizic acid (GA), a natural compound derived from licorice, exhibits notable anti-inflammatory properties.
Aim: Neutrophil extracellular trap (NET) generated by peptidylarginine deiminase 4 (PAD4) has been implicated in the progression of colitis to colitis-associated colorectal cancer (CAC).
J Ethnopharmacol
January 2025
Pharmacy School, Shihezi University, Xinjiang, 832000, China; Xinjiang Key Laboratory of Uygur Medicine, Xinjiang Institute of Materia Medica, Xinjiang, 830000, China. Electronic address:
Ethnopharmacological Relevance: Regan Saibisitan (RGS) is a classic prescription used to treat cough, pneumonia, and other respiratory infections in Uygur medicine. It is a granule composed of 12 kinds of medicinal materials. However, the mechanism by which RGS regulates lung disease remains unclear.
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