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Molecularly imprinted electrochemical sensor to sensitively detect tetramethylpyrazine in Baijiu.
Analyst
January 2025
Jiangsu Province Hi-Tech Key Laboratory for Biomedical Research, School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China.
Tetramethylpyrazine (TMP) is a compound known for its natural health benefits, but current detection methods for TMP are overly expensive and time-consuming. In this study, we developed functional materials with TMP molecular recognition properties using molecularly imprinted technology. As TMP does not produce electrochemical signals in the detection potential range, hexacyanoferrate was selected as a redox probe, combined with the highly conductive polymer PEDOT:PSS to enhance electrode conductivity.
View Article and Find Full Text PDFMapping of Amyloid-β Aggregates In Vivo by a Fluorescent Probe with Dual Recognition Moieties.
Anal Chem
January 2025
State Key Laboratory of Chemical Resource Engineering, College of Chemistry, Beijing University of Chemical Technology, Beijing 100029, China.
The spontaneous aggregation of amyloid-β (Aβ) leads to neuronal cell death in the brain and causes the development of Alzheimer's disease (AD). The efficient detection of the aggregation state of Aβ holds significant promise for the early diagnosis and subsequent treatment of this neurodegenerative disorder. Currently, most of the fluorescent probes used for the detection of Aβ fibrils share similar recognition moieties, such as the ,-dimethylamino group, ,-diethylamino group, and piperidyl group.
View Article and Find Full Text PDFIntegration of histone modification-based risk signature with drug sensitivity analysis reveals novel therapeutic strategies for lower-grade glioma.
Front Pharmacol
January 2025
Department of Neurological Function Examination, Affiliated Hospital of Hebei University, Baoding, China.
Background: Lower-grade glioma (LGG) exhibits significant heterogeneity in clinical outcomes, and current prognostic markers have limited predictive value. Despite the growing recognition of histone modifications in tumor progression, their role in LGG remains poorly understood. This study aimed to develop a histone modification-based risk signature and investigate its relationship with drug sensitivity to guide personalized treatment strategies.
View Article and Find Full Text PDFTailoring of Selective Chemo-Responsiveness in Liquid Crystals via Organic Ionic Plastic Crystals.
Small
January 2025
Department of Chemical Engineering, POSTECH, Pohang, 37673, Republic of Korea.
Liquid crystals (LCs) are widely used as promising stimuli-responsive materials due to their unique combination of liquid and crystalline properties, providing the capability to sense even molecular-scale events and amplify them into macroscopic optical outputs. However, encoding a high level of selectivity to a specific intermolecular event remains a key challenge, leading to prior studies regarding chemically functionalized LC interfaces. Herein, we propose an integrative strategy to significantly advance the design of chemo-responsive LCs through a deep fundamental understanding on the orientational coupling of LCs with new functional molecules, organic ionic plastic crystals (OIs), presented at LC interfaces.
View Article and Find Full Text PDFIntegrating Metal-Organic Framework Hybrid into Nucleic Acid-Based Hydrogel for Highly Selective Recognition and Sensitive Detection of Sarafloxacin.
Anal Chem
January 2025
State Key Laboratory of Food Science and Resources, School of Food Science and Technology, Collaborative Innovation Center of Food Safety and Quality Control of Jiangsu Province, Jiangnan University, Wuxi 214122, China.
Metal-organic framework-based hybrids (MOFzyme) have promising applications in colorimetric aptasensors due to their highly efficient and stable catalytic activity. However, their efficient application in biosensors remains a challenging issue due to the limited reaction site and amorphous structure. Herein, we encapsulated catalase inside MOF cavities to prepare an MOFzyme with many functional groups on its surface, and the functional groups were utilized for the subsequent integration of MOFzyme into the hyaluronic acid-DNA hydrogel.
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