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Updating the relationship of Chlamydia pneumoniae with atherosclerotic cardiovascular diseases: a systematic review of reviews.
New Microbiol
November 2024
Department of Public Health and Infectious Diseases, University of Rome "Sapienza", Rome, Italy.
Chlamydia pneumoniae is the etiologic agent of respiratory tract infections in humans, including community-acquired pneumonia, and has been associated with atherosclerotic cardiovascular diseases. The present systematic review of reviews aimed at answering important questions on the involvement of C. pneumoniae in the pathogenesis of atherosclerosis, its cellular and molecular mechanisms, and whether there is evidence of a causal relationship.
View Article and Find Full Text PDFFatal attractions that trigger inflammation and drive atherosclerotic disease.
Eur J Clin Invest
May 2024
Division of Nephrology, Department of Medicine, McMaster University, The Research Institute of St. Joe's Hamilton and the Hamilton Centre for Kidney Research, Hamilton, Ontario, Canada.
Background: Atherosclerosis is the salient, underlying cause of cardiovascular diseases, such as arrhythmia, coronary artery disease, cardiomyopathy, pulmonary embolism and myocardial infarction. In recent years, atherosclerosis pathophysiology has evolved from a lipid-based to an inflammation-centric ideology.
Methods: This narrative review is comprised of review and original articles that were found through the PubMed search engine.
Engineering a novel immunogenic chimera protein utilizing bacterial infections associated with atherosclerosis to induce a deviation in adaptive immune responses via Immunoinformatics approaches.
Infect Genet Evol
August 2022
USERN Office, Babol University of Medical Sciences, Babol, Iran; Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran; Immunoregulation Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran. Electronic address:
Recent studies have established the role of bacteria including Streptococcus pneumoniae, Helicobacter pylori, Chlamydia pneumonia, Mycobacterium tuberculosis, and Porphyromonas gingivalis in the development of atherosclerosis. These bacteria contribute to plaque formation via promoting Th1 immune responses and speeding up ox-LDL formation. Hence, we employed computational reverse vaccinology (RV) approaches to deviate immune response toward Th2 via engineering a novel immunogenic chimera protein.
View Article and Find Full Text PDFand as Two Emerging Risk Factors in Atherosclerosis: Meta-Analysis Study and Systematic Review.
Infect Disord Drug Targets
May 2022
Department of Biostatistics, Health Faculty, Ilam University of Medical Sciences, Ilam, Iran.
Background: Previous studies suggested an association between Chlamydia pneumoniae and Mycoplasma pneumonia with atherosclerosis, separately. Until now, according to inconsistent information, the relationship between C.pneumoniae and M.
View Article and Find Full Text PDFEffect of coexistence of Chlamydia pneumoniae and increased epicardial fat thickness on coronary artery disease.
Eur Rev Med Pharmacol Sci
March 2021
Cardiology Department, Yuzuncuyil University Faculty of Medicine, Van, Turkey.
Objective: Epicardial fat thickness (EFT) and chlamydia infection are independent cardiovascular risk factors in coronary artery disease (CAD). We aimed to evaluate the effect of coexistence of EFT and chlamydia infection on the presence and severity of CAD in patients with stable angina pectoris (SAP).
Patients And Methods: The study included 208 patients with SAP, divided into a CAD group (n=112) and a control group (n=96).
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