Chiral 1-aminoalkyl chloromethyl ketimines 2 are synthesized in enantiomerically pure form starting from 1-aminoalkyl chloromethyl ketones 1 and different amines. Reduction of amino ketimines 2 and subsequent spontaneous cyclization affords aminoalkyl aziridines 3 with high diastereoisomeric excess and without detectable racemization.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/jo005741x | DOI Listing |
Publication Analysis
Top Keywords
1-aminoalkyl chloromethyl
8
synthesis enantiopure
4
enantiopure alpha-amino
4
alpha-amino ketimines
4
ketimines amino
4
amino aziridines
4
aziridines chiral
4
chiral 1-aminoalkyl
4
chloromethyl ketimines
4
ketimines synthesized
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!