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Contribution of Nuclear Fragmentation to Dose and RBE in Carbon-Ion Radiotherapy.
Radiat Res
January 2025
Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota.
Variable relative biological effectiveness (RBE) of carbon radiotherapy may be calculated using several models, including the microdosimetric kinetic model (MKM), stochastic MKM (SMKM), repair-misrepair-fixation (RMF) model, and local effect model I (LEM), which have not been thoroughly compared. In this work, we compared how these four models handle carbon beam fragmentation, providing insight into where model differences arise. Monoenergetic and spread-out Bragg peak carbon beams incident on a water phantom were simulated using Monte Carlo.
View Article and Find Full Text PDFBiomechanical Behaviors of Molars Restored with Endocrowns Composed of Different Materials.
Materials (Basel)
January 2025
Department of Cariology and Endodontology, Peking University School and Hospital of Stomatology, Beijing 100101, China.
To assess the biomechanical behaviors of endodontically treated molars (ETMs) restored with endocrowns composed of different materials, forty mandibular molars were assigned to five groups (n = 8 each). Untreated molars constituted the control group (group C); the rest of the teeth that underwent root canal therapy were restored with endocrowns composed of polycrystalline ceramics (ST zirconia, UPCERA) in group ZR, lithium disilicate glass ceramics (UP.CAD, UPCERA) in group LD, resin-based nanoceramics (Hyramic, UPCERA) in group NC, and feldspathic ceramics (CEREC Blocs, Sirona) in group FC.
View Article and Find Full Text PDFFrom Serendipity to Precision: Integrating AI, Multi-Omics, and Human-Specific Models for Personalized Neuropsychiatric Care.
Biomedicines
January 2025
HUN-REN-SZTE Neuroscience Research Group, Hungarian Research Network, University of Szeged (HUN-REN-SZTE), Danube Neuroscience Research Laboratory, Tisza Lajos krt. 113, H-6725 Szeged, Hungary.
: The dual forces of structured inquiry and serendipitous discovery have long shaped neuropsychiatric research, with groundbreaking treatments such as lithium and ketamine resulting from unexpected discoveries. However, relying on chance is becoming increasingly insufficient to address the rising prevalence of mental health disorders like depression and schizophrenia, which necessitate precise, innovative approaches. Emerging technologies like artificial intelligence, induced pluripotent stem cells, and multi-omics have the potential to transform this field by allowing for predictive, patient-specific interventions.
View Article and Find Full Text PDFParacetamol, its metabolites, and their transfer between maternal circulation and fetal brain in mono- and combination therapies.
Pharmacol Rep
January 2025
Department of Neuroscience, School of Translational Medicine, Monash University, Melbourne, VIC, 3004, Australia.
Background: Due to its availability and perceived safety, paracetamol is recommended even during pregnancy and for neonates. It is used frequently alone or in combination with other drugs required for the treatment of various chronic conditions. The aim of this study was to investigate potential effects of drug interactions on paracetamol metabolism and its placental transfer and entry into the developing brain.
View Article and Find Full Text PDFImmediate Patient Satisfaction with Dental Esthetics After Endodontic and Prosthodontic Treatment of Dental Dyschromia.
Dent J (Basel)
January 2025
Center for Advanced Technologies in Dental Prosthodontics, Department of Dental Prostheses Technology (Dental Technology), Faculty of Dental Medicine, "Victor Babeș" University of Medicine and Pharmacy Timișoara, Eftimie Murgu Square No. 2, 300041 Timișoara, Romania.
This study aimed to evaluate patients' satisfaction with the esthetic outcomes of combined endodontic and prosthetic treatments for devitalized or dyschromic teeth, a condition influenced by various intrinsic and extrinsic factors that present a growing concern in modern dentistry. A total of 104 patients, including 43 men and 61 women, underwent treatment using lithium disilicate restorations for esthetic zones and zirconium oxide restorations for regions with higher occlusal demands. Patient satisfaction was evaluated through a post-treatment questionnaire, classifying responses as either "satisfied" or "dissatisfied".
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