Objective: To study the prevalence of cavum septum pellucidum (CSP), a midline developmental anomaly, in patients with schizophrenia.
Methods: Three-millimeter coronal T1 weighted MRI images of 43 normal controls and 73 patients with schizophrenia were examined. The images were resampled into 1-mm slices and CSP was measured by the number of slices in which it appeared.
Results: Patients had significantly higher incidence of CSP (Fisher's exact test 0.042; one-sided). Eighteen (41.9%) of the controls and 44 (60.3%) of patients had a CSP, and one of 46 controls and three of 73 patients had a large CSP of six slices or more. There was no relationship between the presence or size of CSP and regional brain volumes or volumes of hippocampus-amygdala complex, caudate, superior temporal gyrus or ventricular CSF.
Conclusion: Higher incidence of CSP may reflect a neurodevelopmental disturbance in schizophrenia.
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Article Synopsis
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- The research involved 175 former players, both college and professional, and compared their CSP measurements to a control group without RHI exposure, assessing associations with cumulative head impact and traumatic encephalopathy syndrome (TES).
- Results indicated that former players had significantly higher CSP presence and ratio compared to controls, with professional players exhibiting an even greater ratio; however, there was no notable link between CSP and TES or provisional
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December 2023
Department of Psychiatry and Psychotherapy, LMU University Hospital, Munich, Germany.
The majority of traumatic encephalopathy syndrome (TES) cases have been reported in former contact sport athletes. This is the first case with TES in a 19-year-old male patient with progressive cognitive decline after daily domestic physical violence through repeated hits to the head for 15 years. The patient presented with a moderate depressive episode and progressive cognitive decline.
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