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Uncovering the Mechanism of Action of Antiprotozoal Agents: A Survey on Photoaffinity Labeling Strategy.
Pharmaceuticals (Basel)
December 2024
Dipartimento di Scienze della Vita, della Salute e delle Professioni Sanitarie, Università degli Studi "Link Campus University", Via del Casale di S. Pio V 44, I-00165 Rome, Italy.
, , and parasites are responsible for infectious diseases threatening millions of people worldwide. Despite more recent efforts devoted to the search for new antiprotozoal agents, efficacy, safety, and resistance issues still hinder the development of suited therapeutic options. The lack of robustly validated targets and the complexity of parasite's diseases have made phenotypic screening a preferential drug discovery strategy for the identification of new chemical entities.
View Article and Find Full Text PDFOccurrence of Leishmania spp. in phlebotomine sand flies and dogs in Guelma region, North-eastern Algeria.
Vet Parasitol Reg Stud Reports
January 2025
Department of Veterinary Medicine, University of Bari, Valenzano, Bari, Italy; Department of Veterinary Clinical Sciences, City University of Hong Kong, Hong Kong. Electronic address:
Leishmania spp. are sand fly-borne parasitic protozoa of worldwide distribution that may severely affect the health and welfare of dogs as well as of other mammalian species, including humans. Algeria is among the most affected countries, counting several cases of Leishmania infantum infection in humans and dogs.
View Article and Find Full Text PDFFirst Comprehensive List of Phlebotomine Sand Fly Species (Diptera: Psychodidae) in a Leishmaniasis Focus (Djelfa, Algeria), Including the First Record of Females in Algeria.
J Arthropod Borne Dis
June 2024
Exploration and Valorization of Steppe Ecosystems Laboratory, Faculty of Nature and Life science, University of Djelfa, Djelfa, Algeria.
Background: The wide distribution of phlebotomine vectors complicates the leishmaniasis situation in the world, with the risk of spreading from rural to urban areas. Our study investigates for the first time the ecology and distribution of sand fly populations in leishmaniasis focus (Djelfa, Algeria).
Methods: Sampling is performed using light traps from August 2021 to July 2022 at ten sites with different biotopes: two peri-urban stations (Ain Oussera and Hassi Bahbah), one urban station (Djelfa), and three rural stations (Ain El-Bel, Haniet Ouled Salem and Mlaga).
Management of Canine Leishmaniasis and the Treatment Trends of Veterinarians in Aegean Region of Türkiye: A Questionnaire-based Survey.
Turkiye Parazitol Derg
January 2025
Ege University Faculty of Medicine, Department of Parasitology, İzmir, Türkiye.
Objective: Canine leishmaniasis (CanL) is an important veterinary and public health problem in Mediterranean countries. Although CanL and vector sandflies are widespread in the study area, there are no standardized diagnostic and treatment methods followed by private clinics. This study aimed to survey (i) the treatment, diagnosis, and control measures preferred by veterinarians, (ii) compare the differences in the first-step diagnostic tests applied, and (iii) identify differences in the guidance for CanL.
View Article and Find Full Text PDFLand use and cover changes and sand fly (Diptera: Psychodidae) assemblages in an emerging focus of leishmaniasis.
Med Vet Entomol
January 2025
Department of Chemistry and Biology, Universidade Estadual do Maranhão, Caxias, Brazil.
Land use and cover changes lead to fragmentation of the natural habitats of sand flies and modify the epidemiological profile of leishmaniasis. This process contributes to the infestation of adjacent rural settlements by vector sand fly species with different degrees of adaptation, promoting leishmaniasis outbreaks. This study aimed to assess land use and cover changes over a 12-year period and investigate the diversity and abundance of sand fly assemblages in the rural area of Codó, Maranhão State, Brazil.
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