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The discovery of a potent intracellular inhibitor of human neutrophil elastase which is orally active and has a long duration of action is described. The pharmacodynamic and pharmacokinetic properties of a trans-lactam development candidate, GW311616A, are described.
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| http://dx.doi.org/10.1016/s0960-894x(01)00078-6 | DOI Listing |
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