Five cases of methaemoglobinaemia, following exposure to industrial waste, are examined, investigated and managed successfully. The condition is discussed in detail.
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A 10-year retrospective review of exposures to volatile nitrites reported to the Victorian Poisons Information Centre.
Clin Toxicol (Phila)
January 2025
Pharmacy Department, Austin Health, Heidelberg, Australia.
Article Synopsis
- Volatile nitrites, like amyl nitrite, are recreationally used for enhanced sexual experiences but can lead to serious health issues, prompting a study from the Victorian Poisons Information Centre covering a decade.
- Over ten years, there was a significant rise in reported cases, with 132 calls about 122 exposures, often linked to ingestion and inhalation; common symptoms included dizziness, irritation, and nausea, while more serious effects occurred in a minority of cases.
- The study highlights the increasing use of volatile nitrites in Australia, underscoring the need for improved community education and harm reduction strategies among users and healthcare providers.
Novel hypothesis for infant methemoglobinemia: Survival and metabolism of nitrite-producers from vegetables under gastrointestinal stress and intestinal adhesion.
Food Res Int
August 2024
Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea. Electronic address:
Infants have digestive environments that are more favorable for microbial proliferation and subsequent endogenous nitrite production than those of adults, but direct evidence of this has been lacking. In this study, we propose a novel epidemiology of infant methemoglobinemia by demonstrating the risk posed by nitrite-producers in the gastrointestinal tract. Nitrite-producers from vegetables (n = 323) were exposed to stress factors of the gastrointestinal environment (gastric pH, intestinal bile salts, anaerobic atmosphere) reflecting 4 different postnatal age periods (Neonate, ≤1 month; Infant A, 1-3 months; Infant B, 3-6 months; Infant C, 6-12 months).
View Article and Find Full Text PDFReal-world safety profile of tetracyclines in children younger than 8 years old: an analysis of FAERS database and review of case report.
Expert Opin Drug Saf
July 2024
Department of Pharmacy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Background: The study aims to obtain the real-world safety profile of tetracyclines in children younger than 8 years old and provide reference for clinical drug applications.
Research Design And Methods: We made a disproportionality analysis of the FDA Adverse Event Reporting System (FAERS) database through OpenVigil 2 and conducted a review of case reports regarding adverse drug reactions (ADRs) of tetracyclines in children younger than 8-year-old.
Results: FAERS analysis identified 32 ADRs of tetracyclines in children younger than 8-year-old.
Causes of acquired methemoglobinemia - A retrospective study at a large academic hospital.
Toxicol Rep
June 2024
Department of Pathology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242, USA.
Methemoglobinemia is a potentially life-threatening condition caused by the formation of methemoglobin, a form of hemoglobin that cannot bind oxygen. While there are some rare congenital causes of methemoglobinemia, most cases are acquired from the effects of specific drugs or environmental exposures. In this retrospective study, we analyzed a large data set of whole blood samples analyzed for methemoglobin at an academic medical center in Midwestern United States that provides both pediatric and adult services.
View Article and Find Full Text PDFPrevalence and phylogenetic traits of nitrite-producing bacteria in raw ingredients and processed baby foods: Potential sources of foodborne infant methemoglobinemia.
Food Res Int
February 2024
Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea. Electronic address:
Article Synopsis
- Nitrite is primarily seen as a chemical hazard that can cause methemoglobinemia in infants, but its presence in food due to nitrite-producing bacteria (NPBs) has not been thoroughly studied.
- In this research, NPBs were isolated from 320 food samples including both raw ingredients and processed baby foods, revealing a significant presence of these bacteria, especially in beetroot and powdered infant formula.
- The study also identified various phyla of NPBs and raised awareness about the potential microbiological risks associated with these bacteria in baby food, emphasizing the need for better recognition of such risks.
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