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Glucocorticoids induce a maladaptive epithelial stress response to aggravate acute kidney injury.
Sci Transl Med
October 2024
Institute of Pharmacology, University of Marburg, Karl-von-Frisch-Straße 2, Marburg 35043, Germany.
Acute kidney injury (AKI) is a frequent and challenging clinical condition associated with high morbidity and mortality and represents a common complication in critically ill patients with COVID-19. In AKI, renal tubular epithelial cells (TECs) are a primary site of damage, and recovery from AKI depends on TEC plasticity. However, the molecular mechanisms underlying adaptation and maladaptation of TECs in AKI remain largely unclear.
View Article and Find Full Text PDFSpectrum of Kidney Biopsy Findings Associated With Methamphetamine Use.
Kidney Int Rep
July 2024
Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, California, USA.
Article Synopsis
- Methamphetamine (METH) is widely used and known to cause significant kidney dysfunction, but research on its specific toxic effects on the kidneys is limited.
- A study of 112 METH-abusing patients revealed that almost all had kidney issues, with common conditions including acute tubular necrosis (ATN) and focal segmental glomerulosclerosis (FSGS).
- The findings suggest that METH use frequently results in acute kidney injury (AKI) and associated proteinuria, highlighting the need for better understanding and management of renal complications in METH users.
A histological examination of the effects of extract on kidney and liver tissues in myoglobinuric acute renal failure.
Biotech Histochem
April 2024
Department of Medical Laboratory Techniques, Health Services Vocational School, Toros University, Mersin, Turkey.
Myoglobinuric acute renal failure (MARF) is a structural and functional disorder that occurs in the kidney following the release of muscle cell contents into the circulation. In this present study, possible protective and curative effects of extract against kidney and liver damage in experimentally induced MARF in a rat model were investigated. 3-4 Month-old, 200-250 g Sprague Dawley rats were divided into 8 equal groups with 7 rats per group.
View Article and Find Full Text PDFMyosin heavy-chain myopathy in 2 American quarter horses.
Vet Pathol
May 2024
Texas A&M University, College Station, TX.
A 1.5-year-old American quarter horse gelding (case 1) and an 11-month-old American quarter horse filly (case 2) were presented for acute onset pelvic lameness and lethargy. Case 1 had nasal discharge, while case 2 developed rapid muscle atrophy.
View Article and Find Full Text PDFAntisynthetase Syndrome: The Classical Phenotype With a Twist.
Cureus
July 2023
Department of Nephrology, General Hospital of Trikala, Trikala, GRC.
Antisynthetase syndrome is a systemic autoimmune rheumatic disease characterized by multiple organ involvement, including interstitial lung disease, myositis, non-erosive arthritis, fever, Raynaud's phenomenon, "mechanic's hands," and the presence of autoantibodies against aminoacyl-tRNA synthetases, mainly anti-Jo1 (histidyl) antibodies. Patients with antisynthetase syndrome and active muscle inflammation are usually presented with elevated creatine phosphokinase levels, even in the range of acute rhabdomyolysis. Despite that, the presence of myoglobinuric acute kidney injury is rarely seen in patients with myositis-associated rhabdomyolysis.
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