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A Rapid Cognitive and Motor Decline: A Case of Misdiagnosed Sporadic Creutzfeldt-Jakob Disease.
Cureus
November 2024
Acute Medicine, Peterborough City Hospital, Peterborough, GBR.
Creutzfeldt-Jakob disease (CJD) is a fatal neurodegenerative disorder that leads to rapid cognitive decline, dementia, and neurological deterioration. CJD has several forms, including sporadic CJD (sCJD), which accounts for most cases, and variant CJD (vCJD), linked to exposure to bovine spongiform encephalopathy (BSE or mad cow disease). The disease is caused by abnormal prion proteins, which damage the brain and lead to death.
View Article and Find Full Text PDFPractical strategies for caring for patients with functional neurological disorder in the ED.
Emerg Med Australas
October 2024
Department of Neurology, Princess Alexandra Hospital, Brisbane, Queensland, Australia.
Article Synopsis
- Functional Neurological Disorder (FND) presents challenges in the emergency department due to varied and vague symptoms, necessitating a compassionate and systematic approach to patient care.
- Clear communication, validation of symptoms, and thorough history-taking are vital for building trust and ensuring appropriate diagnoses and treatments.
- A multidisciplinary approach that includes physiotherapy and psychological support, along with careful consideration for comorbid conditions, can enhance patient outcomes and support effective management of FND.
The Neuroconnective Endophenotype, a New Approach Toward Typing Functional Neurological Disorder: A Case-Control Study.
J Neuropsychiatry Clin Neurosci
January 2025
Mental Health Institute, Hospital del Mar, Barcelona, Spain (Bulbena-Vilarrasa, Martínez-García, Pérez-Sola); Doctorate Program, Psychiatry and Forensic Medicine Barcelona, Universitat Autònoma de Barcelona, Barcelona, Spain (Bulbena-Vilarrasa, Martínez-García); Centro de Investigación Biomédica en Red de Salud Mental, Instituto de Salud Carlos III-ES, Madrid (Bulbena-Vilarrasa, Pintor Pérez, Pérez-Sola); Consultation Liaison Psychiatry Unit, Department of Psychiatry and Psychology, Hospital Clinic de Barcelona, Institute of Neuroscience Barcelona, Barcelona, Spain (Pintor Pérez, Camara, Arbelo-Cabrera); Department of Medicine, School of Medicine Barcelona, University of Barcelona, Barcelona, Spain (Pintor Pérez); August Pi i Sunyer Institute of Biomedical Research Barcelona, Catalunya, Spain (Pintor Pérez); Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York (Bulbena-Cabré); Facultad de Ciencias de la Salud y de la Vida, Universitat Pompeu Fabra, Barcelona, Spain (Pérez-Sola); Laboratoire de Psychopathologie et Processus de Santé, Université Paris Cite, Paris, Île-de-France, France (Baeza-Velasco); Department of Emergency Psychiatry and Acute Care, Montpellier 2 University, Montpellier, Occitanie, France (Baeza-Velasco); University of Montpellier, Centre National de la Recherche Scientifique, Inserm, Institute of Functional Genomics, Montpellier, Occitanie, France (Baeza-Velasco).
Article Synopsis
- Functional neurological disorder (FND) is a condition with both physical and mental symptoms, and a new phenotype called neuroconnective endophenotype (NEP) has been linked to anxiety and joint hypermobility.
- A study involving 27 FND patients and 27 healthy controls revealed that FND patients demonstrated greater sensory sensitivity, higher rates of hypermobility, more psychiatric and physical comorbidities, and more anxiety-related symptoms.
- The findings suggest that the NEP could help categorize FND patients, offering a better understanding of their complex physical and mental health issues.
Locus coeruleus co-activation patterns at rest show higher state persistence in patients with dissociative seizures: A Pilot Study.
Epilepsia Open
December 2024
Department of Neurology, University Hospital Essen, Essen, Germany.
Objective: Dissociative seizures are paroxysmal disruptions of awareness and behavioral control in the context of affective arousal. Alterations in stress-related endocrine function have been demonstrated, but the timescale of dissociation suggests that the central locus coeruleus (LC) noradrenergic system is likely pivotal. Here, we investigate whether LC activation at rest is associated with altered brain network dynamics.
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