This paper outlines the principles of a conceptual foundation for an innovative approach to the training of the modern psychotherapist, using certain technical and philosophical percepts found in the practice of Zen, divorced from its usual role as a form of Buddhism and/or a religious belief. A set of core principles derived from Zen and embedded in psychoanalytic theory are listed. Specific values are embodied in the day to day practice of the psychotherapist. The first of these values is the understanding of the true nature of emptiness in relation to the self and the non-Cartesian universe. Then the concept of impermanence and the centrality of paradox to the practice of Zen and psychotherapy is described. The basis of this approach to the education of the psychotherapist is grounded in the assumption that the usual training format with its focus on training in technical skills, with personal treatment being an additional requirement for many psychodynamic therapists, is insufficient for a complete educational experience. The training of the mind itself is an often forgotten and yet essential component of the training process.
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http://dx.doi.org/10.1176/appi.psychotherapy.2001.55.1.1 | DOI Listing |
Nat Commun
January 2025
Department of Applied Physics, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan.
Recent studies on topological materials are expanding into the nonlinear regime, while the central principle, namely the bulk-edge correspondence, is yet to be elucidated in the strongly nonlinear regime. Here, we reveal that nonlinear topological edge modes can exhibit the transition to spatial chaos by increasing nonlinearity, which can be a universal mechanism of the breakdown of the bulk-edge correspondence. Specifically, we unveil the underlying dynamical system describing the spatial distribution of zero modes and show the emergence of chaos.
View Article and Find Full Text PDFBioorg Chem
January 2025
Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal, Academy of Higher Education, Manipal, Karnataka 576104, India.
Fragment-Based Drug Discovery (FBDD) has revolutionized drug discovery by overcoming the challenges of traditional methods like combinatorial chemistry and high-throughput screening (HTS). Leveraging small, low-molecular-weight fragments, FBDD achieves higher hit rates, reduced screening costs, and faster development timelines for clinically relevant drug candidates. This review explores FBDD's core principles, innovative methodologies, and its success in targeting diverse protein classes, including previously "undruggable" targets.
View Article and Find Full Text PDFBMC Infect Dis
January 2025
Princess Srisavangavadhana College of Medicine, Chulabhorn Royal Academy, Bangkok, Thailand.
Introduction: Early antibiotic administration is one of the core treatments of sepsis which associated with reduced mortality rate. However, the appropriate timing of antibiotics remains a controversial issue, especially in patients without septic shock. Here, we reported the outcomes of early antibiotic administration within one hour from the time of infection suspicion in a tertiary care hospital.
View Article and Find Full Text PDFMonash Bioeth Rev
January 2025
Faculty of Arts and Sciences, American University of Beirut, Riad El Solh, Beirut, 1107 2020, Lebanon.
Thoracoabdominal normothermic regional perfusion (TA-NRP), a new method of controlled donation after circulatory death, seems to provide more and better organs for patients on organ transplant waiting lists compared to standard controlled donation after circulatory death. Despite its benefits, the ethical permissibility of TA-NRP is currently a highly debated issue. The recent statement published by the American College of Physicians (ACP) highlights the reasons for these debates.
View Article and Find Full Text PDFJ Med Internet Res
January 2025
Research Centre Jülich, Institute of Neuroscience and Medicine, Brain and Behaviour (INM-7), Jülich, Germany.
Background: Traditional in-clinic methods of collecting self-reported information are costly, time-consuming, subjective, and often limited in the quality and quantity of observation. However, smartphone-based ecological momentary assessments (EMAs) provide complementary information to in-clinic visits by collecting real-time, frequent, and longitudinal data that are ecologically valid. While these methods are promising, they are often prone to various technical obstacles.
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