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Japan has resumed its health technology assessment to decide how to reduce high-cost drug prices. While drug price rules in Japan are comprehensive, they do not necessarily capture differences in product characteristics. This study examined the drug price revision strategy in Japan using migraine treatment with triptans as an example.

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Objective: To compare all licensed drug interventions as oral monotherapy for the acute treatment of migraine episodes in adults.

Design: Systematic review and network meta-analysis.

Data Sources: Cochrane Central Register of Controlled Trials, Medline, Embase, ClinicalTrials.

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Article Synopsis
  • New migraine treatments like lasmiditan and CGRP antagonists (rimegepant and ubrogepant) have been developed, providing alternatives to traditional triptans.
  • A systematic review analyzed clinical trials comparing these new treatments against triptans for their effectiveness in managing acute migraine pain.
  • Results indicated that while most treatments reduced pain at 2 hours, triptans generally showed better outcomes for both pain freedom and pain relief compared to lasmiditan, rimegepant, and ubrogepant.
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Objectives: Headache during migraine attack may recur during a single attack. The present study evaluated efficacy of both individual and combined use of agents from nonsteroidal anti-inflammatory drug (NSAID) and triptan groups widely used in treatment of migraine attacks.

Methods: A total of 201 attacks in 67 migraine patients were evaluated.

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