Antibacterial effects of trisubstituted quinazoline derivatives.

Folia Microbiol (Praha)

Department of Biochemistry and Microbiology, Faculty of Chemical Technology, Slovak University of Technology, 812 37 Bratislava, Slovakia.

Published: May 2001

Five trisubstituted quinazolones and eight trisubstituted quinazoline-4-thiones have been tested for antibacterial effects by a microdilution method. Four derivatives exerted a significant effect on E. coli, P. aeruginosa, S. aureus and B. subtilis (IC50 < 100 mg/L). In the bacterium P. aeruginosa six quinazolines showed a higher antibacterial effect than ampicillin. The most sensitive to the effects of the quinazolines was S. aureus; a concentration of 100 mg/L of six derivatives induced a bacteriostatic effect on S. aureus. The quinazoline-4-thiones were generally more active than the quinazolones. All the tested concentrations of the four most effective quinazolines influenced the specific growth rate.

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Source
http://dx.doi.org/10.1007/BF02817411DOI Listing

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