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Leonurine Inhibits Hepatic Lipid Synthesis to Ameliorate NAFLD via the ADRA1a/AMPK/SCD1 Axis.
Int J Mol Sci
October 2024
School of Traditional Chinese Medicine, Jinan University, Guangzhou 510632, China.
Article Synopsis
- Leonurine, a compound derived from the Lamiaceae plant, shows potential benefits in treating nonalcoholic fatty liver disease (NAFLD) due to its anti-oxidative, anti-apoptotic, and metabolic regulation properties, though its exact mechanisms are not fully understood.
- In a study involving mice, different groups were treated with leonurine and other treatments to observe changes in liver health after a high-fat high-sugar diet, revealing that leonurine positively influenced lipid metabolism-related genes.
- Further analysis indicated that leonurine may lower lipid levels by activating the AMPK signaling pathway and affecting lipid molecules, specifically through the ADRA1a/AMPK/SCD1 axis, thus improving liver lipid
Determination of tacrolimus in human whole blood in kidney transplant recipients using a rapid and specific LC-MS/MS method.
J Clin Lab Anal
August 2023
Institute of Biomedicine and Pharmacy, Vietnam Military Medical University, Hanoi, Vietnam.
Objective: To develop and validate an LC-M/SMS method for the determination of tacrolimus in human whole blood.
Method: The LC-MS/MS method for the determination of tacrolimus in whole blood was developed and validated according to the guidelines. Concentrations of TAC in 100 kidney transplant patients measured by LC-MS/MS were compared with CMIA using correlation analysis and Bland-Altman plots.
Genome mining to identify valuable secondary metabolites and their regulation in Actinobacteria from different niches.
Arch Microbiol
March 2023
Biotechnology Group, Biological Sciences and Technology Division, CSIR-North East Institute of Science and Technology, Jorhat, 785006, Assam, India.
Actinobacteria are the largest bacteria group with 18 significant lineages, which are ubiquitously distributed in all the possible terrains. They are known to produce more than 10,000 medically relevant compounds. Despite their ability to make critical secondary metabolites and genome sequences' availability, these two have not been linked with certainty.
View Article and Find Full Text PDFFK506 increases susceptibility to musculoskeletal infection in a rodent model.
BMC Musculoskelet Disord
July 2022
Combat Wound Care, U.S. Army Institute of Surgical Research, JBSA-Fort Sam Houston, TX, 78234, USA.
Background: Delayed fracture healing caused by soft tissue loss can be resolved by the administration of a Th1 immunosuppressant, such as FK506. Additionally, open fractures are at high risk for infection. We hypothesized that the inclusion of an immunosuppressant to a subject at risk for a musculoskeletal infection will increase the likelihood of infection.
View Article and Find Full Text PDFA text messaging intervention and quality of life in adolescents with solid organ transplants.
Pediatr Transplant
May 2022
Division of Cardiology, Department of Pediatrics, BC Children's Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
Background: Facilitating communication between adolescents and HCP outside of appointments may enhance patient experience and outcomes. The purpose of this study was to determine whether SMS enhances the healthcare experience, QoL, and medication adherence in adolescent SOT patients.
Methods: This was a prospective observational study of an SMS platform (WelTel Inc) for SOT patients aged 12-19 years.
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