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Anticancer Potential of the Cyclolinopeptides.
Cancers (Basel)
July 2023
Institute of Biochemistry, Graz University of Technology, 8010 Graz, Austria.
Novel therapeutic agents to combat cancer is an active area of research, as current treatment options have limitations in efficacy and tolerability. One of these therapeutic agents in our immediate environment is cyclolinopeptides (CLPs). CLPs have several advantages that make them suitable for daily consumption and potential therapeutics in cancer research.
View Article and Find Full Text PDFFlaxseed Peptides and Cyclolinopeptides: A Critical Review on Proteomic Approaches, Biological Activity, and Future Perspectives.
J Agric Food Chem
November 2022
State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, Jiangxi 330047, People's Republic of China.
Linusorbs (LOs) and peptides from flaxseed protein have documented biological activity, such as angiotensin-converting enzyme inhibition, antioxidant, anticancer, and immunosuppressive activities, but their mechanism and structure-related bioactivity have not been summarized previously. Therefore, this study reviews the structure, composition, bioavailability, and health benefits of flaxseed peptides and LOs as well as peptide generation and LO modification. However, these peptides and LOs are long linear and cyclic structures, which affect the absorption and bioavailability of these substances in living beings and, thus, impair their overall efficiency and pharmacological effectiveness.
View Article and Find Full Text PDFHealth benefits of flaxseed and its peptides (linusorbs).
Crit Rev Food Sci Nutr
August 2024
Department of Food and Bioproduct Sciences, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Flaxseed ( L.) has been associated with numerous health benefits. The flax plant synthesizes an array of biologically active compounds including peptides or linusorbs (LOs, .
View Article and Find Full Text PDFThe Potential Role of Cyclopeptides from , and , and Peptides Derived from Heterophyllin B as Dipeptidyl Peptidase IV Inhibitors for the Treatment of Type 2 Diabetes: An In Silico Study.
Metabolites
April 2022
Graduate Institute of Biotechnology, National Chung Hsing University, Taichung 402202, Taiwan.
Dipeptidyl peptidase 4 (DPP4) inhibitors can treat type 2 diabetes by slowing GLP-1 degradation to increase insulin secretion. Studies have reported that , (flaxseed), and , plants rich in Caryophyllaceae-type cyclopeptides and commonly used as herbal or dietary supplements, are effective in controlling blood sugar. The active site of DPP4 is in a cavity large enough to accommodate their cyclopeptides.
View Article and Find Full Text PDFNatural cyclic polypeptides as vital phytochemical constituents from seeds of selected medicinal plants.
Arch Pharm (Weinheim)
April 2021
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, AIMST University, Bedong, Kedah, Malaysia.
Cyclopolypeptides are among the most predominant biomolecules in nature, especially those derived from plant seeds. This category of compounds has gained extraordinary attention due to remarkable variety of structures and valuable biofunctions. These congeners display enormous variation in terms of both structure and function and are the most significant biomolecules due to their widespread bioproperties.
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