AI Article Synopsis
- Researchers developed strong inhibitors for glycogen synthase kinase-3 (GSK-3) using an automated method.
- Many of these inhibitors are highly selective and don't significantly affect over 20 other protein kinases.
- This specificity could lead to better therapeutic options with fewer side effects.
Article Abstract
Potent 3-anilino-4-arylmaleimide glycogen synthase kinase-3 (GSK-3) inhibitors have been prepared using automated array methodology. A number of these are highly selective, having little inhibitory potency against more than 20 other protein kinases.
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| http://dx.doi.org/10.1016/s0960-894x(00)00721-6 | DOI Listing |
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