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Enhancing the effectiveness of immunotherapy in rheumatoid arthritis by delaying immunosenescence triggered by fibroblast-like synoviocytes.
J Orthop Surg Res
January 2025
Department of Rheumatology, Lanzhou University Second Hospital, Lanzhou University, No. 80, Cuiyingmen, Chengguan District, Lanzhou, Gansu Province, 730030, China.
Rheumatoid arthritis (RA) is a prevalent autoimmune disorder primarily targeting the diarthrodial joints. During the progression of RA, fibroblast-like synoviocytes (FLSs) exhibit tumor-like behavior, including increased proliferation, inflammation mediation, and aggressive phenotypes, leading to bone erosion. Additionally, T cells in RA acquire pro-inflammatory characteristics, exacerbating the inflammatory environment in affected joints and associated tissues.
View Article and Find Full Text PDFMorphology of the sternoclavicular joint and its microanatomical changes in response to osteoarthritic degeneration.
Clin Anat
December 2024
Anatomy, Biomedical Sciences, University of Edinburgh, Edinburgh, UK.
Although the sternoclavicular joint shares structural similarities with the knee and hip joints as a diarthrodial joint, its biomechanics differ significantly due to its non-weight-bearing nature. Nevertheless, it is subject to considerable loading, leading to increased susceptibility to osteoarthritis, a prevalent condition characterized by the degeneration of the joint's articular surfaces and fibrocartilaginous intra-articular disc. The osteoarthritic degeneration of the fibrocartilaginous and cartilaginous surfaces of the sternoclavicular joint has been investigated, considering multiple factors.
View Article and Find Full Text PDFSacroiliac dysfunction and minimally invasive sacroiliac joint fusion.
Tech Vasc Interv Radiol
September 2024
Interventional Spine Services, Comprehensive Specialty Care, Edmond, OK.
The sacroiliac joint (SIJ) is the largest diarthrodial joint in the human body and accounts for approximately 20% of all low back pain, which is commonly seen in patients with lumbosacral fusions. Despite this, SIJ dysfunction often poses a challenging diagnosis depending on clinical evaluation, imaging, and image-guided joint injection. SIJ fusion is an effective and safe method of treatment, with minimally invasive approaches fitting well within the armamentarium of interventional radiologists treating chronic pain and other musculoskeletal conditions.
View Article and Find Full Text PDFFibrodysplasia ossificans progressiva emerges from obscurity.
Trends Mol Med
September 2024
Department of Medicine, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Article Synopsis
- * The ACVR1 mutations disrupt normal bone growth and influence various bodily systems, including inflammation, wound healing, and pain sensitivity.
- * The article discusses the complex features of FOP, suggests ways to address these symptoms, and identifies critical gaps in current knowledge about the disorder.
Exploring Cardiovascular Risk Factors and Atherosclerosis in Rheumatoid Arthritis.
Eur J Intern Med
October 2024
Department of Rheumatology, School of Health Sciences, Faculty of Medicine, University of Ioannina, Ioannina, Greece.
Rheumatoid arthritis (RA) is a chronic inflammatory disease mainly affecting the peripheral diarthrodial joints symmetrically and also presenting many extra-articular manifestations. Morbidity and mortality in RA patients are higher compared to the general population. Cardiovascular (CV) disease is one of the most common causes of death in these patients.
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