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http://dx.doi.org/10.1093/embo-reports/kvd103 | DOI Listing |
Adv Exp Med Biol
April 2008
Walter and Eliza Hall Institute of Medical Research, Victoria, Australia.
To date, there are no vaccines against any of the major parasitic diseases including leishmaniasis, and chemotherapy is the main weapon in our arsenal. Current drugs are toxic and expensive, and are losing their effectiveness due to parasite resistance. The availability of the genome sequence of two species of Leishmania, Leishmania major and Leishmania infantum, as well as that of Trypanosoma brucei and Trypanosoma cruzi should provide a cornucopia of potential new drug targets.
View Article and Find Full Text PDFEMBO Rep
November 2000
National Institute for Cancer Research-IST, Advanced Biotechnology Center, Genova, Italy.
Mol Med Today
August 1997
Dept of Internal Medicine I, Saarland University Medical School, Homburg, Germany.
Specific vaccines for the immunotherapy of human neoplasms require specific human tumor antigens. While efforts to identify such antigens by the analysis of the T-cell repertoire have yielded few antigens, the application of SEREX, the serological identification of antigens by recombinant expression cloning, has brought a cornucopia of new antigens. Several specific antigens have been identified in each tumor tested, suggesting that many human tumors elicit multiple immune responses in the autologous host.
View Article and Find Full Text PDFPediatr Ann
November 1996
University of Southern California School of Medicine, Division of Infectious Diseases, Children's Hospital, Los Angeles 90027, USA.
Antimicrobial therapy of infection in ambulatory children remains the cornerstone of the pediatrician's practice. Despite a cornucopia of newer antimicrobial agents, the older "tried and true" drugs continue to be favored based on their history of effectiveness, lack of toxicity, and low price. It also is clear that the widespread use of antimicrobial agents has contributed to the development of resistance.
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