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Background: Occurrence of life-threatening scorpion sting in adults is a rare entity compared with children. Different cases of organ failure following scorpion sting have been reported but complications, such as acute toxic myocarditis, cardiogenic shock, pulmonary edema, acute kidney injury and toxic hepatitis occurring simultaneously in adult patients is exceedingly rare with no prior documented similar report. This case report explores the unique presentation of these complications occurring simultaneously and their management in resource limited setting.
View Article and Find Full Text PDFA compendium of Amplification-Related Gain Of Sensitivity genes in human cancer.
Nat Commun
January 2025
European Research Institute for the Biology of Ageing, University Medical Center Groningen, Groningen, Netherlands.
While the effect of amplification-induced oncogene expression in cancer is known, the impact of copy-number gains on "bystander" genes is less understood. We create a comprehensive map of dosage compensation in cancer by integrating expression and copy number profiles from over 8000 tumors in The Cancer Genome Atlas and cell lines from the Cancer Cell Line Encyclopedia. Additionally, we analyze 17 cancer open reading frame screens to identify genes toxic to cancer cells when overexpressed.
View Article and Find Full Text PDFMedicinal Plants and Home Remedies for Scorpion Sting Envenomation: Why Proven Therapies Should Take Precedence Pending Robust Evidence.
Toxicon
January 2025
Epidemiología, Unidad de Medicina Familiar No. 53, Instituto Mexicano del Seguro Social, Zapopan, Jalisco, México; Programa de posgrado de la especialidad en Epidemiología, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, Guadalajara, Jalisco, México.
Endemic Scorpion Species and Subspecies in Morocco: A Comprehensive Overview.
Toxicon
January 2025
Laboratory of Venoms and Toxins, Pasteur Institute of Morocco. Electronic address:
Scorpion fauna is abundant in regions with arid and semi-arid climates, exposing these areas to a risk of envenomation, especially for children. Scorpion envenomations cause thousands of deaths each year, with notable incidences in the MENA region, South America, Latin and Central America, and India. Morocco is one of the countries most affected by this phenomenon; according to statistics from the Moroccan Poison Control and Pharmacovigilance Center (CAPM), approximately 8,565 scorpion stings and envenomations were recorded annually between 2016 and 2022, mainly among children.
View Article and Find Full Text PDFNew biomarkers in scorpion stings.
Toxicon
January 2025
Department of Internal Medicine, Faculty of Medicine, Federal University of Minas Gerais (UFMG), Brazil; Interdisciplinary Research Center in Intensive Care Medicine (NIIMI), Brazil. Electronic address:
Scorpion stings have a fatality rate of 0.16%, with the majority of deaths occurring in children. The resources currently available for diagnosing cardiac dysfunction caused by scorpion stings, the most common cause of death, are echocardiograms and laboratory tests, such as troponin, creatine phosphokinase-MB (CKMB), and Brain natriuretic peptide (BNP).
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