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DT-13 Mediates Ligand-Dependent Activation of PPARγ Response Elements In Vitro.
Biology (Basel)
December 2024
Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Diagnostic Laboratory Medicine, Clinical Chemistry and Pathobiochemistry, Augustenburger Platz 1, D-13353 Berlin, Germany.
Activation of inflammatory pathways releases a storm of cytokines. Moreover, unregulated cytokines contribute to chronic inflammatory disorders. However, ligand-activated peroxisome proliferator-activated receptor gamma (PPARγ) is involved in suppressing inflammatory cytokines via transrepression of nuclear factor kappa B (NFκB).
View Article and Find Full Text PDFThiazolidinedione derivatives in cancer therapy: exploring novel mechanisms, therapeutic potentials, and future horizons in oncology.
Naunyn Schmiedebergs Arch Pharmacol
December 2024
Department of Pharmacy, School of Health Sciences, Central University of South Bihar, Gaya, 824236, India.
Thiazolidinedione derivatives have shown significant potential as targeted cancer therapies by leveraging their various mechanisms of action. These include suppressing cell proliferation, triggering apoptosis, and influencing signaling pathways associated with tumor development. Their multifaceted effects make them promising candidates for advancing cancer treatment strategies.
View Article and Find Full Text PDFMitigation of polystyrene microplastic-induced hepatotoxicity in human hepatobiliary organoids through bile extraction.
Ecotoxicol Environ Saf
December 2024
Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8102, Japan. Electronic address:
Background & Aims: Polystyrene microplastics (PS-MPs) are pervasive in our daily life and can be ingested by the human body through bioaccumulation, causing organ damage, especially liver damage. However, the effect of PS-MPs bioaccumulation on human hepatotoxicity and their metabolism remains unclear. Recent studies have demonstrated that PS-MPs cause lipid and bile acid metabolism disorders.
View Article and Find Full Text PDFTroglitazone reduces intracellular Mycobacterium tuberculosis survival via macrophage autophagy through LKB1-AMPKα signaling.
J Infect Dis
October 2024
National Clinical Research Center for Infectious Diseases, Guangdong Provincial Clinical Research Center for Tuberculosis, Shenzhen Third People's Hospital, Southern University of Science and Technology, Shenzhen, 518112, China.
Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb), results in significant morbidity and mortality worldwide. Host-directed therapy (HDT), including conventional drugs, is a promising anti-TB strategy that shows synergistic antibacterial effects when combined with anti-TB drugs. Here, the mycobactericidal effect of three anti-diabetic drugs was examined.
View Article and Find Full Text PDFUnveiling the shield: Troglitazone's impact on epilepsy-induced nerve injury through ferroptosis inhibition.
CNS Neurosci Ther
August 2024
Department of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, P.R. China.
Article Synopsis
- Epilepsy affects around 50 million people worldwide, with many patients facing drug-refractory conditions despite available anti-epileptic drugs, indicating a need for new treatment options.
- This study investigates troglitazone (TGZ) as a potential neuroprotective agent against seizures and neuronal damage, employing both in vitro and in vivo models to assess its effects.
- Results showed that TGZ significantly reduced seizure severity and neuronal damage by inhibiting ferroptosis, preventing mitochondrial changes, and demonstrating efficacy in both cell models of toxicity.
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