Effect of vitamin E on human sperm motility and lipid peroxidation in vitro.

Asian J Androl

Department of Biophysics, Panjab University, Chandigarh 160014, India.

Published: September 1999

AI Article Synopsis

  • The study aimed to evaluate how vitamin E can protect sperm against damage caused by reactive oxygen species (ROS), focusing on its effects on sperm motility, viability, and lipid peroxidation.
  • Human semen samples were analyzed in a lab setting, with varying concentrations of vitamin E applied to observe its impact on sperm health.
  • Results showed that vitamin E improved sperm motility and viability while reducing malondialdehyde levels, indicating its potential importance for preserving sperm during storage.

Article Abstract

Aim: To assess the protective efficacy of vitamin E to counteract the reactive oxygen species (ROS) mediated damage on sperm motility, viability and lipid peroxidation.

Methods: Human semen samples were obtained from the local hospital. The split seminal fractions freed of seminal plasma were reconstituted in Ringer-Tyrode and subjected to varied vitamin E concentrations (0.1-2 mmol/L).

Results: Dose-dependent improvement in both motility and viability accompanied by concomitant decrease in malondialdehyde (MDA--an end product of lipid peroxidation) following vitamin E supplementation was noticed.

Conclusion: Vitamin E protects against the ROS mediated damage on spermatozoa. Vitamin E supplementation could be of clinical importance for prolonged spermatozoal storage whenever needed.

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