The paper presents the method elaborated by the authors for production, storage and implantation of embryonal nervous tissue (ENT). Extracerebral implantation was performed in 33 epileptic patients aged 2-58 years. Clinical state of the patients and EEG alterations were studied. Before treatment the patients' mental status was characterized by affective disorders, dysphoria, depression, exhaustion of mental processes, varying intellectual-mnestic decrease and behavioral disinhibition. Oligophrenia as of debility was observed in several cases. After implantation the pronounced positive changes in both paroxysmal states and overall mental status were observed in all the cases irrespective of their age of the patients. These clinical changes correlated with the dynamics of EEG changes (EEG changes were not observed in 2 individuals with positive clinical effects).
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Infect Dis (Lond)
September 2022
Université de Lorraine, CHRU-Nancy, Infectious and Tropical Diseases, Nancy, France.
Rofo
October 2022
Institute of Radiology and Neuroradiology, Evangelisches Krankenhaus, Medical Campus University of Oldenburg, Germany.
Background: Recently introduced MRI techniques offer improved image quality and facilitate examinations of patients even when artefacts are expected. They pave the way for novel diagnostic imaging strategies in neuroradiology. These methods include improved 3D imaging, movement and metal artefact reduction techniques as well as Dixon techniques.
View Article and Find Full Text PDFCurr Neuropharmacol
May 2022
Neuropharmacology Research Laboratory, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway, Selangor, Malaysia.
Background: Epilepsy is a devastating neurological disorder that affects nearly 70 million people worldwide. Epilepsy causes uncontrollable, unprovoked and unpredictable seizures that reduce the quality of life of those afflicted, with 1-9 epileptic patient deaths per 1000 patients occurring annually due to sudden unexpected death in epilepsy (SUDEP). Predicting the onset of seizures and managing them may help patients from harming themselves and may improve their well-being.
View Article and Find Full Text PDFPain
October 2018
Center for Interdisciplinary Magnetic Resonance, The National High Magnetic Field Laboratory, Florida State University, Tallahassee, FL, United States.
Under the hypothesis that increased extracellular sodium induces sustained neuronal excitability with the onset and progression of migraine, this study evaluates dynamic in vivo Na fluxes in the brain of a preclinical rodent analogue of migraine. Ultra-high field Na magnetic resonance imaging (MRI) at 21.1 T has demonstrated potential to quantify sodium concentrations with good spatial and temporal resolution after the onset of central sensitization.
View Article and Find Full Text PDFBackground/aims: The management of extracerebral collections of fluid in patients with hydrocephalus can be problematic for either their simultaneous separate management or sequential management, each of which may require multiple surgeries and the management of external drains. The object of this report is to review the experience with a shunt configuration that simultaneously diverts ventricular fluid and extracerebral fluid, whether subdural or subarachnoid in location, through different outflow resistances.
Methods: The medical records, including neuroimaging of patients with hydrocephalus and clinically significant extracerebral collections of low density who were managed by implanting a differential pressure type shunt, were retrospectively reviewed.
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