AI Article Synopsis
- A study compared eight lambdoid phages, focusing on their immunity regions, specifically the repressor and CRO proteins and their operator sequences.
- The cross immunity observed between phages VT2-Sa and lambda was traced to similarities in their genetic sequences.
- Additionally, the resemblance between 933W and HK022's recognition helices suggests they may share similar immunity specificity, allowing researchers to identify the previously unknown OL and PL regions in phage 933W.
Article Abstract
Comparison of eight lambdoid phages, including three Shiga-toxin converting phages, has been carried out with respect to the immunity region, especially the recognition helices of their repressor and CRO proteins on the one hand, and operator sequences on the other. Some as yet unassigned components of the regulatory circuits have been inferred by computer search. The cross immunity phenomenon shown by phages VT2-Sa and lambda is explained on the basis of similarity in their sequences. In addition, the similarity of 933W and HK022 in the sequences of their recognition helices of repressor and CRO, on the one hand, and operators, on the other, has led us to predict that they will have identical or similar immunity specificity. This homology has enabled us also to locate the OL (and consequently PL) of phage 933W that has been thought to be non-existent.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1266/ggs.75.223 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!