Nebulization of solutions associating gomenol, dexamethasone and framycetin is very widespread in otorhinolaryngology (particularly for the treatment of actue laryngitis and post-traumatic laryngitis and rhinitis and for the tracheotomy care). A rigorous clinical evaluation is however lacking. The aim of this work was to evaluate use of such solutions in comparison with the recommendations issuing from the National Session in April 1997 on good practices for aerosol therapeutics. Stability and granulometry were studied in order to optimize processing. A new formulation and new technical methods of administration are proposed in relation to the results of this study and the national recommendations.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Cold Consolidation of Pharmaceutical Waste Glass Powders Through Alkali Activation and Binder Jet 3D Printing.
Materials (Basel)
October 2024
Department of Industrial Engineering, University of Padova, 35131 Padova, Italy.
The recent COVID-19 emergency has led to an impressive increase in the production of pharmaceutical vials. This has led to a parallel increase in the amounts of waste glass; manufacturers typically recover material from faulty containers by crushing, giving origin to an unrecyclable fraction. Coarse fragments are effectively reused as feedstock for glass melting; on the contrary, fine powders (<100 microns), contaminated by metal and ceramic particles due to the same crushing operations, are landfilled.
View Article and Find Full Text PDFSpray-drying of PEI-/PPI-based nanoparticles for DNA or siRNA delivery.
Eur J Pharm Biopharm
June 2024
Rudolf-Boehm-Institute for Pharmacology and Toxicology, Clinical Pharmacology, Leipzig University, Faculty of Medicine, Härtelstraße 16-18, 04107 Leipzig, Germany. Electronic address:
Spray-drying of nucleic acid-based drugs designed for gene therapy or gene knockdown is associated with many advantages including storage stability and handling as well as the possibility of pulmonary application. The encapsulation of nucleic acids in nanoparticles prior to spray-drying is one strategy for obtaining efficient formulations. This, however, strongly relies on the definition of optimal nanoparticles, excipients and spray-drying conditions.
View Article and Find Full Text PDFEffect of replacing durum wheat semolina with larvae powder on the techno-functional properties of the binary blends.
Curr Res Food Sci
December 2023
Department of Biotechnology and Food Analysis, Wroclaw University of Economics and Business, Wroclaw, Poland.
(TM) larvae, due to their high nutritional value, are gaining growing attention in food and feed sectors. Although few studies dealt with wheat-based products functionalized with TM larvae powder, there is a lack of comprehensive characterization of the raw materials to optimize the formulations for end-product recommendation. This study aimed at investigating the effects of partial replacement of durum wheat semolina with increasing amounts of TM larvae powder (5-30%) on the techno-functional properties of the binary blends.
View Article and Find Full Text PDFMineralogical fingerprint and human health risk from potentially toxic elements of Fe mining tailings from the Fundão dam.
Sci Total Environ
February 2024
Department of Chemistry and Physics, Federal University of Espírito Santo, Alegre, Espírito Santo 29500-000, Brazil.
In 2015, >50 million cubic meters of Fe mining tailings were released into the Doce River basin from the Fundão dam, raising the question of its consequences on the affected ecosystems. This study aimed to establish a mineralogical-(geo)chemical association of potentially toxic elements (PTEs) from Fe mining tailings from the Fundão dam, collected seven days after the failure, through a multidisciplinary approach combining assessment of the risk to human health, environmental geochemistry, and mineralogy. Thus, eleven tailings samples were collected with the support of the Brazilian Military Police Fire Department.
View Article and Find Full Text PDFis a tropical plant with red calyxes whose anthocyanins, phenols, and antioxidant activity make it attractive to consumers both from a nutritional and medicinal standpoint. Its seasonality, perishability, and anthocyanin instability, led to the setup of stabilization methods comprising drying and powdering. However, its properties can often be altered during these stabilization processes.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!