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Steroid hormone catabolites activate the pyrin inflammasome through a non-canonical mechanism.
Cell Rep
October 2022
CIRI, Centre International de Recherche en Infectiologie, Inserm U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, University Lyon, 69007 Lyon, France. Electronic address:
The pyrin inflammasome acts as a guard of RhoA GTPases and is central to immune defenses against RhoA-manipulating pathogens. Pyrin activation proceeds in two steps. Yet, the second step is still poorly understood.
View Article and Find Full Text PDFPyrogenicity of etiocholanolone and interleukin-1 in New and Old World Monkeys.
Proc Soc Exp Biol Med
April 1998
New York University Medical Center, Laboratory for Experimental Medicine and Surgery in Primates, Tuxedo 10987, USA.
Etiocholanolone (5beta-androstan-3alpha-ol-17-one; designated E) is one of the major products of metabolism of testosterone and androstenedione (androst-4-ene-3,17-dione) in many mammalian species, including humans. E and several other 5beta-reduced steroids have been found to induce fever in humans. The pyrogenic effect of these steroids has been shown to be due to the release of interleukin-1 (IL-1) from the leukocytes that are mobilized in response to the steroid injections.
View Article and Find Full Text PDF[A case of familial Mediterranean fever with obvious family history].
Nihon Naibunpi Gakkai Zasshi
December 1994
Third Department of Internal Medicine, Faculty of Medicine, Kyusyu University.
A 26-year-old female was admitted to our hospital on December 4, 1992, because of recurrent fever. She had experienced recurrent fever of over 38 degrees C, occurring at irregular intervals 4-6 times a year with chest or abdominal pain, since the age of 19. After delivery of a baby at the age of 25, her symptoms had increased to once a week.
View Article and Find Full Text PDFModulatory effect of hyperthermia on hepatic microsomal cytochrome P450 in mice.
Biochem Pharmacol
July 1993
Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada.
It is widely known that the clearance of drugs is often compromised during episodes of infectious disease via a down-regulation of cytochrome P450 (P450) at a pre-translational step in enzyme synthesis. Etiocholanolone (ETC), a potent inflammatory agent, induces fever in humans and causes a decrease in the clearance of certain drugs that are metabolized by P450. On this basis it is widely believed that the fever per se rather than the immune modulation that occurs during infections may have a major role in depression of microsomal P450 enzymes during viral infections in humans.
View Article and Find Full Text PDF["Etiocholanolone fever"?].
Dtsch Med Wochenschr
June 1992
Deutsche Klinik für Diagnostik, Wiesbaden.
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