Cytokine expression in the brain has been suggested to mediate various sickness behaviors. Here we report that intraperitoneal injection of a Corynebacterium parvum antigen in C57BL/6 mice was followed by prolonged upregulation of cytokines in the cerebral cortex and subcortical structures in a time course that coincided with reduced spontaneous running activity.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC96078 | PMC |
| http://dx.doi.org/10.1128/CDLI.8.2.446-448.2001 | DOI Listing |
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