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Senolytic Vaccines from the Central and Peripheral Tolerance Perspective.
Vaccines (Basel)
December 2024
Research Center for Translational Medicine, Sirius University of Science and Technology, Federal Territory Sirius, Krasnodarsky Krai, Sirius 354349, Russia.
Preventive medicine has proven its long-term effectiveness and economic feasibility. Over the last century, vaccination has saved more lives than any other medical technology. At present, preventative measures against most infectious diseases are successfully used worldwide; in addition, vaccination platforms against oncological and even autoimmune diseases are being actively developed.
View Article and Find Full Text PDFBiomedical Application Prospects of Gadolinium Oxide Nanoparticles for Regenerative Medicine.
Pharmaceutics
December 2024
Department of Hospital Surgery, Department of Plastic and Reconstructive Surgery, Cosmetology and Cell Technology, Pirogov Russian National Research Medical University (RNRMU), 117997 Moscow, Russia.
Background/objectives: The aim was to study the possibilities of biomedical application of gadolinium oxide nanoparticles (GdO NPs) synthesized under industrial conditions, and evaluate their physicochemical properties, redox activity, biological activity, and safety using different human cell lines.
Methods: The powder of GdO NPs was obtained by a process of thermal decomposition of gadolinium carbonate precipitated from nitrate solution, and was studied using transmission electron microscopy (TEM), X-ray diffraction (XRD), Raman spectroscopy, mass spectrometry, and scanning electron microscopy (SEM) with energy dispersive X-ray analyzer (EDX). The redox activity of different concentrations of GdO NPs was studied by the optical spectroscopy (OS) method in the photochemical degradation process of methylene blue dye upon irradiation with an optical source.
Fabrication and Characterization of Phyllanthus Emblica Extract-Polyvinyl Alcohol/Carboxymethyl Cellulose Sodium Antioxidant Hydrogel and Its Application in Wound Healing.
Pharmaceutics
November 2024
Henan Provincial People's Hospital, Zhengzhou 450003, China.
: Phyllanthus emblica is a medicinal and edible plant from the Euphorbiaceae family, notable for its rich content of polyphenols and flavonoids, which provide significant antioxidant properties. To exploit the full antioxidant potential of Phyllanthus emblica, this study developed a hydrogel system incorporating polyvinyl alcohol (PVA) and carboxymethyl cellulose sodium (CMC-Na), integrated with Phyllanthus emblica extract, for the purpose of wound healing. : The extraction process of active ingredients of Phyllanthus emblica was optimized and assessed the antioxidant composition and activity of the extract.
View Article and Find Full Text PDFRecent Advances in Polyurethane for Artificial Vascular Application.
Polymers (Basel)
December 2024
College of Materials Science and Engineering, Wuhan Textile University, Wuhan 430070, China.
Artificial blood vessels made from polyurethane (PU) have been researched for many years but are not yet in clinical use. The main reason was that the PU materials are prone to degradation after contact with blood and will also cause inflammation after long-term implantation. At present, PU has made progress in biostability and biocompatibility, respectively.
View Article and Find Full Text PDFStudy on the Characterization of Physical, Mechanical, and Creep Properties of Masson Pine and Chinese Fir Wood Flour-Reinforced High-Density Polyethylene Composites.
Polymers (Basel)
December 2024
Special and Key Laboratory for Development and Utilization of Guizhou Superior Bio-Based Materials, Guizhou Minzu University, Guiyang 550025, China.
Improving the physical, mechanical, and creep properties of wood fiber-reinforced polymer composites is crucial for broadening their application prospect. In this research, seven types of high-density polyethylene (HDPE) composites reinforced with different mass ratios of Masson pine ( Lamb.) and Chinese fir [ (Lamb.
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