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Complex water networks visualized by cryogenic electron microscopy of RNA.
Nature
March 2025
Biophysics Program, Stanford University School of Medicine, Stanford, California, USA.
The stability and function of biomolecules are directly influenced by their myriad interactions with water. In this study, we investigated water through cryogenic electron microscopy (cryo-EM) on a highly solvated molecule, the Tetrahymena ribozyme, determined at 2.2 and 2.
View Article and Find Full Text PDFSurgical extraction of a cannula tip embedded in the neck after liposuction at an external facility: a case report.
Arch Craniofac Surg
February 2025
Department of Plastic and Reconstructive Surgery, Gachon University College of Medicine, Incheon, Korea.
Liposuction is a widely performed aesthetic plastic surgery procedure used for various purposes. The use of advanced liposuction techniques has reduced the risk of complications. Nevertheless, they can still occur unexpectedly.
View Article and Find Full Text PDFA Perplexing Case Highlighting the Diagnostic Conundrum of Miliary Tuberculosis Mimicking Sarcoidosis and Progressing Into Hemophagocytic Lymphohistiocytosis.
Cureus
February 2025
Internal Medicine, AdventHealth, Orlando, USA.
Establishing the diagnosis of miliary tuberculosis (TB) can be challenging due to the heterogeneous clinical presentations and low sensitivity of diagnostic tests. Miliary TB shares overlapping clinical, radiological, and histopathological features with other chronic granulomatous diseases, such as sarcoidosis, often posing a significant diagnostic challenge for clinicians. A 36-year-old male from Haiti presented with a four-month history of recurrent fever, dry cough, night sweats, and weight loss.
View Article and Find Full Text PDFCucurbit[7]uril-Styryl dye complexes for Fluorescent Recognition of DNA and Cell Imaging.
Chembiochem
March 2025
INEOS RAN: FGBUN Institut elementoorganiceskih soedinenij imeni A N Nesmeanova Rossijskoj akademii nauk, Laboratory of Photoactive Supramolecular Systems, Vavilova St. 28, 119991, Moscow, RUSSIAN FEDERATION.
This paper focused on the DNA-binding properties of novel dicationic cyanine dyes, in which pyridinium centers are linked by bridges of different functionalities. We found that dye 1, bearing a flexible butyl-4-methylpyridinium terminal fragment, has the ability to bind to the DNA groove. The attachment of a quite rigid para-xylylene-4-methylpyridinium unit as a terminal group in dye 2 contributed to dual DNA-binding modes: intercalation and groove binding.
View Article and Find Full Text PDFIsthmic spondylolisthesis combined with schwannoma occurring at the same vertebral level: a case report and literature review.
Front Surg
February 2025
Department of Spine Surgery, China-Japan Union Hospital of Jilin University, Changchun, China.
Background: The occurrence of schwannomas at the level of isthmic spondylolisthesis has not yet been reported. Preoperative identification of the responsible lesion and a rational surgical plan are essential for successful surgery.
Case Presentation: We report the case of a 56-year-old woman who presented with a six-year history of low back pain and a three-year history of radiating pain in the left lower extremity.
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