Sensory nerve potential area measurements may reflect the properties of underlying nerve fibres better than amplitude or conduction velocity measures. The terminal segment of the sensory curve may contain activity of regenerating nerve fibres. The reliability of area measurements of sensory potentials obtained with surface recording techniques is unknown. We scanned sural nerve sensory potential curves and measured the areas under different parts of the curve in 52 reference and 73 diabetic polyneuropathy (DPN) patients. The variability of repeat testing in reference subjects for total area was 12% and for the terminal segmental area (TSA) was 19%. In DPN patients, the total area variability was 17% and TSA variability was 24%. This compares to amplitude variability of 8% in reference subjects and 10% in patients with DPN. These results demonstrate that sensory potential area measurements are feasible, but highly variable. We conclude that current clinical trials do not include sufficient numbers of patients to show change in area measurements, particularly the area under the terminal segment of the curve.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Diagnosing Epilepsy with Normal Interictal EEG Using Dynamic Network Models.
Ann Neurol
January 2025
Department of Neurology, Comprehensive Epilepsy Center, Johns Hopkins University, Baltimore, MD, USA.
Objective: Whereas a scalp electroencephalogram (EEG) is important for diagnosing epilepsy, a single routine EEG is limited in its diagnostic value. Only a small percentage of routine EEGs show interictal epileptiform discharges (IEDs) and overall misdiagnosis rates of epilepsy are 20% to 30%. We aim to demonstrate how network properties in EEG recordings can be used to improve the speed and accuracy differentiating epilepsy from mimics, such as functional seizures - even in the absence of IEDs.
View Article and Find Full Text PDFAtmospheric Deposition of Microplastics in South Central Appalachia in the United States.
ACS EST Air
January 2025
Department of Civil and Environmental Engineering, Virginia Tech, Blacksburg, Virginia 24061, United States.
Due to the increased prevalence of plastic pollution globally, atmospheric deposition of microplastics (MPs) is a significant issue that needs to be better understood to identify potential consequences for human health. This study is the first to quantify and characterize atmospheric MP deposition in the Eastern United States. Passive sampling was conducted at two locations within the Eastern United States, specifically in remote South Central Appalachia, from March to September 2023.
View Article and Find Full Text PDFSpatiotemporal Mapping of Ultrafine Particle Fluxes in an Office HVAC System with a Diffusion Charger Sensor Array.
ACS EST Air
January 2025
Lyles School of Civil & Construction Engineering, Purdue University, West Lafayette, Indiana 47907, United States.
Commercial HVAC systems intended to mitigate indoor air pollution are operated based on standards that exclude aerosols with smaller diameters, such as ultrafine particles (UFPs, D ≤ 100 nm), which dominate a large proportion of indoor and outdoor number-based particle size distributions. UFPs generated from occupant activities or infiltrating from the outdoors can be recirculated and accumulate indoors when they are not successfully filtered by an air handling unit. Monitoring UFPs in real occupied environments is vital to understanding these source and mitigation dynamics, but capturing their rapid transience across multiple locations can be challenging due to high-cost instrumentation.
View Article and Find Full Text PDFImpacts of Aging and Relative Humidity on Properties of Biomass Burning Smoke Particles.
ACS EST Air
January 2025
Environmental Engineering Program, University of Colorado Boulder, 1111 Engineering Drive, Boulder, Colorado 80309-0428, United States.
Quantifying changes in the properties of smoke aerosols under varying conditions is important for understanding the health and environmental impacts of exposure to smoke. Smoke composition, aerosol liquid water content, effective density (ρ), and other properties can change significantly as smoke travels through areas under different ambient conditions and over time. During this study, we measured changes in smoke composition and physical properties due to oxidative aging and exposure to humidity.
View Article and Find Full Text PDFComparison of Cardiac Magnetic Resonance Imaging Findings and Prognostic Measures in Nondilated Cardiomyopathy and Dilated Cardiomyopathy.
Cardiol Res Pract
January 2025
Cardiovascular Research Center, Rajaie Cardiovascular Institute, Tehran, Iran.
Nondilated left ventricular cardiomyopathy (NDLVC) is a newly defined category of cardiomyopathy. We sought to evaluate and compare the phenotype of NDLVC with DCM using cardiac magnetic resonance (CMR) imaging and to investigate the prognostic significance of these conditions. One hundred and fifty patients suspected of having cardiomyopathy referred for CMR were recruited.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!