[Relations between ankylosing spondyloarthritis and HLA-B27 in various ethnic groups in Russia].

Aim: To characterize relationship between prevalence of ankylosing spondylarthritis (ASA) and incidence rate of HLA-B27 in genotypically different ethnic groups of Russia with interpolation of the results to other populations.

Material And Methods: 2287 individuals from genotypically different ethnic groups were examined in overall one-stage epidemiological trial.

Results: Prevalence of ASA in ethnic groups ranged from 0.2 to 2.0% while occurrence of HLA0B27--from 15 to 40%. Rate of correlation between the disease prevalence and incidence of B27 was 0.82. The equation for calculation of ASA incidence rate by HLA-B27 incidence was devised: AC(%) = -0.40 + 0.06x.

Conclusion: In most world populations prevalence of ASA correlates with population frequency HLA-B27 though in some ethnic groups this correlation is absent. Consequently, ASA is genetically heterogenous.