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Autoimmune pulmonary alveolar proteinosis developed during treatment for systemic sclerosis: a case report.
BMC Pulm Med
January 2025
Department of Pulmonary Medicine, National Hospital Organization MinamiKyushu Hospital, 1882 Kida, Aira-Shi, Kagoshima, 899-5293, Japan.
Background: Reports of autoimmune diseases coexisting with autoimmune pulmonary alveolar proteinosis (autoimmune PAP; APAP) are extremely rare. APAP coexisting with autoimmune diseases may often be misdiagnosed as connective tissue disease-associated interstitial lung disease (ILD). Here, we describe a rare case of a patient with systemic sclerosis who was diagnosed with APAP after the exacerbation of lung opacities during treatment with immunosuppressive agents.
View Article and Find Full Text PDFThe Coexistence of and Enhanced Biofilm Thickness but Induced Less Severe Neutrophil Responses and Less Inflammation in Pneumonia Mice Than Alone.
Int J Mol Sci
November 2024
Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.
Due to the possible coexistence of (KP) and (CA), strains of KP and CA with biofilm production properties clinically isolated from patients were tested. The production of biofilms from the combined organisms (KP+CA) was higher than the biofilms from each organism alone, as indicated by crystal violet and z-stack immunofluorescence. In parallel, the bacterial abundance in KP + CA was similar to KP, but the fungal abundance was higher than CA (culture method), implying that CA grows better in the presence of KP.
View Article and Find Full Text PDFAssociation of Vitamin D with Haematological Inflammatory Indices in Patients with Back Pain.
J Coll Physicians Surg Pak
November 2024
Department of Physical Medicine and Rehabilitation, Harran University, Sanliurfa, Turkiye.
Objective: To assess the relationship between vitamin D and haematological inflammatory indices (HII) in chronic low back pain (CLBP) patients.
Study Design: Descriptive study. Place and Duration of the Study: Harran University Hospital, Sanliurfa, Turkiye, between September 2023 and February 2024.
Streptococcus anginosus orchestrates antibacterial potential of NETs facilitating survival of accompanying pathogens.
Microbiol Res
January 2025
Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology of Jagiellonian University, Krakow, Poland. Electronic address:
Streptococcus anginosus is considered an emerging opportunistic pathogen causing life-threatening infections, including abscesses and empyema. Noticeably, clinical data revealed that S. anginosus also constitutes an important component of polymicrobial infections.
View Article and Find Full Text PDFConquering dual challenges: A sialic acid-modified liposome for targeting activated neutrophils to tackle comorbid lung inflammation and cancer metastasis.
J Control Release
December 2024
School of Pharmaceutical Science, Liaoning University, Shenyang 110036, China; Liaoning Key Laboratory of New Drug Research & Development, Shenyang 110036, China. Electronic address:
In clinical settings, cancer frequently coexists with multi-system diseases. Owing to compromised immune systems, patients with cancer exhibit an increased susceptibility to infections and inflammation. Notably, lung inflammation occurs with high incidence among these patients.
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