A flow cytometry analysis in children and adolescents with osteosarcoma was carried out. Investigation concerned 32 fresh surgical specimens (from patients after preoperative chemotherapy) and 18 paraffin-embedded tumour tissues (archive material). The correlation of aneuploidy population parameters to malignancy grading acc. to WHO (GI-GIII) and MSC histopathological classification, was investigated. It was shown that all specimens with aneuploid populations correlated with the histophatological diagnosis of osteosarcoma. Thus cytometry analysis can be a useful and rapid complementary method to conventional histophtatological diagnosis. On the contrary, no correlation was found between the aneuploid parameters and the low grade and high-grade osteosarcoma acc. to WHO and MSC classification. The Multicycle computer system is useful in retrospective analysis of paraffin-embedded tumour tissues. It is suggested that for this kind of investigation fresh diagnostic specimens (before preoperative chemotherapy) would be more adequate.
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