AI Article Synopsis
- A 61-year-old man with chronic hepatitis B developed a YMDD mutant after 13 months of lamivudine therapy; despite this, the therapy continued.
- Acute exacerbation of his condition occurred 25 months later, prompting the use of interferon (IFN)-alpha.
- The treatment with IFN-alpha led to a quick decrease in hepatitis B virus DNA, resolved hepatitis, and improved his overall health.
Article Abstract
A 61-year-old man with chronic hepatitis B was treated with interferon (IFN)-alpha for flare-up after the emergence of a lamivudine-induced YMDD motif mutant. The YMDD mutant emerged 13 months after the initiation of lamivudine therapy. Despite this, lamivudine therapy was continued. Acute exacerbation occurred 25 months after the emergence of the YMDD mutant. Treatment with IFN-alpha resulted in rapid loss of hepatitis, B virus DNA, resolution of hepatitis, and clinical recovery.
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| http://dx.doi.org/10.1007/s005350170143 | DOI Listing |
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