Aim: In patients with and without a permanent pacemaker His bundle ablation was performed for symptomatic drug-refractory atrial fibrillation. This study was performed to examine the complications of temporary pacing in patients without an already implanted pacemaker.
Methods And Results: Between January 1996 and December 1998, 152 consecutive patients, both referred and our own (non-referred), underwent His bundle ablation for drug-refractory atrial fibrillation. Primary end-point complications were temporary lead dislodgement requiring immediate repositioning (1), severe arrhythmia (2), death (3) and persistent damage to an already implanted pacing system (4). Secondary end-points were malsensing and malpacing of the temporary lead, and blood vessel problems. Lead dislodgement of the temporary pacemaker occurred in three patients (2.9%), all of whom were in the referred group. Severe arrhythmia and death did not occur. Persistent damage of the already implanted pacing system was not observed. Secondary end-points occurred in 15.8%) of the patients and were successfully managed by a conservative approach.
Conclusion: Permanent pacemaker implantation is recommended prior to His bundle ablation in order to avoid haemodynamic deterioration due to dislocation of the temporary pacemaker lead. RF current used for His bundle ablation caused no permanent damage to permanent pacing systems.
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http://dx.doi.org/10.1053/eupc.2000.0111 | DOI Listing |
Heart Rhythm O2
December 2024
Department of Cardiovascular Medicine, Kyorin University School of Medicine, Mitaka, Japan.
Background: Junctional rhythm (JR) frequently occurs during radiofrequency (RF) ablation procedures targeting the slow pathway (SP) for atrioventricular nodal re-entrant tachycardia (AVNRT), signaling successful ablation. Two types of JR have been noticed: typical JR as His activation preceding atrial activation, and atypical JR as atrial activation preceding the His activation. Nevertheless, the origin and characteristics of JR remain incompletely defined.
View Article and Find Full Text PDFExpert Rev Med Devices
January 2025
Cardiology Unit, "Card. G. Panico" Hospital, Tricase (Le), Italy.
Introduction: In patients with symptomatic, refractory atrial fibrillation the ablate and pace (A&P) strategy (pacemaker implantation followed by atrio-ventricular junction ablation (AVJA)) is superior to medical therapy in improving quality of life and prognosis. Despite its well-proven benefits, this invasive therapeutic option is still underutilized in clinical practice. The choice of pacing modality (right ventricular pacing, biventricular pacing, BVP, or conduction system pacing, CSP) is crucial and can have significant clinical implications.
View Article and Find Full Text PDFHeart Rhythm
December 2024
Geisinger Heart Institute, Wilkes Barre, Pennsylvania.
Background: Left bundle branch (LBB) pacing (LBBP) has gained rapid adoption. Evidence for direct LBB capture has varied from 30%-95% depending on the criteria.
Objective: The purpose of this study was to assess the feasibility and efficacy of intraprocedural transthoracic echocardiographic guidance to achieve LBB capture.
Front Mol Neurosci
December 2024
Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN, United States.
Introduction: The prostate is densely innervated like many visceral organs and glands. However, studies to date have focused on sympathetic and parasympathetic nerves and little attention has been given to the presence or function of sensory nerves in the prostate. Recent studies have highlighted a role for sensory nerves beyond perception of noxious stimuli, as anterograde release of neuropeptides from sensory nerves can affect vascular tone and local immune responses.
View Article and Find Full Text PDFMicrobiol Res
December 2024
Institute of Microbiology, College of Life Sciences, Zhejiang University, Hangzhou 310058, China. Electronic address:
Hydrophobins are small amphiphilic proteins that confer filamentous fungal hydrophobicity needed for hyphal growth, development, dispersal and adhesion to host and substrata. In insect-pathogenic Beauveria bassiana, nine hydrophobins (class I Hyd1A-F and class II Hyd2A-C) were proven to localize on the cell walls of aerial hyphae and conidia but accumulate in the vacuoles and vesicles of submerged hyphae and blastospores, respectively. Conidial hydrophobicity, adhesion to insect cuticle, virulence via normal cuticle infection and dispersal potential were significantly more reduced by the hyd1A deletion leading to complete ablation of slender rodlets on conidial coat than the hyd1B deletion, which caused a failure to assemble morphologically irregular rodlets into orderly bundles.
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