AI Article Synopsis
- The study aimed to assess how effective dynamic contrast-enhanced magnetic resonance imaging (DCEMRI) is in differentiating between remaining or recurring bladder tumors and changes caused by radiation therapy.
- Forty patients with confirmed bladder carcinoma underwent imaging before radiotherapy and at 4 and 12 months post-treatment, with results compared to cystoscopic biopsies.
- The findings indicated that DCEMRI has high negative predictive values for detecting tumor recurrence, suggesting it can be a reliable method to rule out persistent tumors after radiation therapy up to one year later.
Article Abstract
Aim: To evaluate the role of dynamic contrast-enhanced magnetic resonance imaging (DCEMRI) in distinguishing residual or recurrent tumour from radiation change in patients with bladder carcinoma.
Materials And Methods: Forty patients with biopsy proven bladder carcinoma were imaged before and at 4 and 12 months after radiotherapy (XRT) using conventional and dynamic contrast-enhanced magnetic resonance imaging at 0.5 Tesla. An enhancement of >1.54 times above baseline at 80 s post-contrast injection proved a reliable indicator of tumour before radiotherapy and was therefore applied to the assessment of patients after XRT. Conventional MR images and dynamic enhancement profiles (DEPs) from the site of previous tumour were scored by three radiologists for the presence of tumour at 4 and 12 months after XRT. Findings were compared with cystoscopic biopsy.
Results: Dynamic contrast-enhanced magnetic resonance imaging had negative predictive values of 100% and 93% for tumour recurrence at 4 and 12 months, respectively. The positive predictive values, sensitivity and specificity were 48, 100 and 48% at 4 months and 50, 80 and +76% at 12 months post XRT, respectively.
Conclusion: Dynamic contrast-enhanced magnetic resonance imaging may prove reliable in excluding the presence of persistent or recurrent tumour up to 12 months after XRT.
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| http://dx.doi.org/10.1053/crad.2000.0560 | DOI Listing |
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