The irreversible shift in anchorage independence by phorbol ester responsive mouse epidermal cell lines appears to occur not by a mechanism involving selection of preexisting transformants but by induction of a new phenotype.
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Choice Matters: The Moderating Effect of Choice on the Relationship Between Mental Health Personal Recovery and Symptomatology.
J Adolesc Health
February 2025
Silver School of Social Work, New York University, New York, New York.
Purpose: Limited research examines how choice surrounding treatment impacts mental health recovery among young adults with serious mental illness (SMI) who are navigating symptom management, complex mental health systems, and developmental expectations of increased independence. This study examines whether perceived choice related to mental health treatment impacts the relationship between symptomatology and personal recovery among Black, Latino/e, and multiracial young adults with SMI.
Methods: Surveys were conducted with 121 young adults with SMI attending a community-based personal recovery-oriented program.
Unlabelled: Stress granules (SGs) are dynamic cytoplasmic structures assembled in response to various stress stimuli that enhance cell survival under adverse environmental conditions. Here we show that SGs contribute to breast cancer progression by enhancing the survival of cells subjected to anoikis stress. SG assembly is triggered by inhibition of Focal Adhesion Kinase (FAK) or loss of adhesion signals.
View Article and Find Full Text PDFAnchorage Dependence and Cancer Metastasis.
J Korean Med Sci
May 2024
Department of Pharmacology, Yonsei University College of Medicine, Seoul, Korea.
The process of cancer metastasis is dependent on the cancer cells' capacity to detach from the primary tumor, endure in a suspended state, and establish colonies in other locations. Anchorage dependence, which refers to the cells' reliance on attachment to the extracellular matrix (ECM), is a critical determinant of cellular shape, dynamics, behavior, and, ultimately, cell fate in nonmalignant and cancer cells. Anchorage-independent growth is a characteristic feature of cells resistant to anoikis, a programmed cell death process triggered by detachment from the ECM.
View Article and Find Full Text PDFTestis-specific serine kinase 6 (TSSK6) is abnormally expressed in colorectal cancer and promotes oncogenic behaviors.
J Biol Chem
June 2024
Department of Pharmacology, UT Southwestern Medical Center, Dallas, Texas, USA. Electronic address:
Cancer testis antigens (CTAs) are a collection of proteins whose expression is normally restricted to the gamete but abnormally activated in a wide variety of tumors. The CTA, Testis-specific serine kinase 6 (TSSK6), is essential for male fertility in mice. The functional relevance of TSSK6 to cancer, if any, has not previously been investigated.
View Article and Find Full Text PDFYogurt Prevents Colorectal Tumorigenesis in Apc Mice.
Mol Nutr Food Res
May 2024
State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, 214122, China.
Scope: Yogurt consumption is related to a decreased risk of colorectal cancer (CRC), but whether such association is causal remains unclear. Patients with familial adenomatous polyposis (FAP) are at increased risk of CRC development. Here, the study investigates the efficacy of yogurt for intestinal polyposis chemoprevention in Apc mice, a preclinical model for human FAP.
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