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The BabySeq Project: A clinical trial of genome sequencing in a diverse cohort of infants.
Am J Hum Genet
October 2024
Department of Medicine, Mass General Brigham, Boston, MA 02115, USA; Ariadne Labs, Boston, MA 02215, USA; Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Efforts to implement and evaluate genome sequencing (GS) as a screening tool for newborns and infants are expanding worldwide. The first iteration of the BabySeq Project (2015-2019), a randomized controlled trial of newborn sequencing, produced novel evidence on medical, behavioral, and economic outcomes. The second iteration of BabySeq, which began participant recruitment in January 2023, examines GS outcomes in a larger, more diverse cohort of more than 500 infants up to one year of age recruited from pediatric clinics at several sites across the United States.
View Article and Find Full Text PDFCognitive and psychiatric symptom trajectories 2-3 years after hospital admission for COVID-19: a longitudinal, prospective cohort study in the UK.
Lancet Psychiatry
September 2024
Department of Psychiatry, University of Oxford, Oxford, UK; Oxford Health NHS Foundation Trust, Oxford, UK; NIHR Oxford Health Biomedical Research Centre, Oxford, UK.
Background: COVID-19 is known to be associated with increased risks of cognitive and psychiatric outcomes after the acute phase of disease. We aimed to assess whether these symptoms can emerge or persist more than 1 year after hospitalisation for COVID-19, to identify which early aspects of COVID-19 illness predict longer-term symptoms, and to establish how these symptoms relate to occupational functioning.
Methods: The Post-hospitalisation COVID-19 study (PHOSP-COVID) is a prospective, longitudinal cohort study of adults (aged ≥18 years) who were hospitalised with a clinical diagnosis of COVID-19 at participating National Health Service hospitals across the UK.
Mass Spectral Library for DNA Adductomics.
Chem Res Toxicol
February 2024
Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, United States.
Article Synopsis
- Endogenous electrophiles, radiation, and environmental chemicals can damage DNA by creating covalent adducts, which may lead to mutations and cancer if not repaired.
- Identifying and quantifying these DNA adducts is crucial for understanding their impact on cancer development and assessing exposure risks to harmful substances.
- A new DNA adduct mass spectral database and associated portal has been created to centralize and provide access to the spectral data, aiding researchers in studying the effects of DNA adducts on health.
Baseline characteristics of a prospective cohort study of aging and cardiovascular diseases among people living with HIV.
HIV Med
December 2023
Centre de recherche du Centre Hospitalier de l'Université de Montreal (CRCHUM), Montreal, Quebec, Canada.
Article Synopsis
- The Canadian HIV and Aging Cohort Study (CHACS) aims to gather baseline characteristics of participants and has extended its research efforts to 2024, with new assessments being added to the protocol.
- A total of 1,049 participants were recruited, primarily consisting of older males living with HIV, who showed significant socio-economic and health differences compared to non-HIV participants.
- The study's updated protocol aims to provide deeper insights into the aging process for HIV-positive individuals, emphasizing the need to consider socio-economic and cardiovascular factors in future analyses.
Perinatal outcomes in women living with HIV-1 and receiving antiretroviral therapy-a systematic review and meta-analysis.
Acta Obstet Gynecol Scand
February 2022
Department of Obstetrics and Gynecology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.
Introduction: Antiretroviral therapy-naïve pregnant women living with HIV are at an increased risk for adverse pregnancy outcomes. It remains controversial whether this risk persists with antiretroviral therapy. We conducted a systematic review and meta-analysis to evaluate whether pregnant women living with HIV and receiving antiretroviral therapy antenatally, are at an increased risk of adverse outcomes compared with HIV-negative controls.
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