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Peroxyredoxin 6 Protects RIN-M5F Pancreatic Beta Cells Against Streptozotocin-Induced Senescence.
Cell Physiol Biochem
September 2024
Institute of Cell Biophysics, FSC PBCRAS, Institutskaya str., 3, Pushchino, Moscow region, 142290, Russia.
Background/aims: There are evidences that a decrease in the functional activity of pancreatic β-cells under type 2 diabetes conditions may be associated with their senescence, therefore, senotherapy may be a prospective strategy for the diabetes treatment.
Methods: The senotherapeutic potential of peroxiredoxin 6 (PRDX6) was studied in RIN-m5F pancreatic β-cells with streptozotocin-induced senescence by measuring markers, associated with senescence.
Results: Exposure to streptozotocin (STZ) resulted in the senescence of the β-cells.
New insights into posttranslational modifications of proteins during bull sperm capacitation.
Cell Commun Signal
April 2023
Department of Gamete and Embryo Biology, Institute of Animal Reproduction and Food Research of Polish Academy of Sciences, 10-748, Olsztyn, Poland.
Background: Due to the unique nature of spermatozoa, which are transcriptionally and translationally silent, the regulation of capacitation is based on the formation of posttranslational modifications of proteins (PTMs). However, the interactions between different types of PTMs during the capacitation remain unclear. Therefore, we aimed to unravel the PTM-based regulation of sperm capacitation by considering the relationship between tyrosine phosphorylation and reversible oxidative PTMs (oxPTMs), i.
View Article and Find Full Text PDFRed blood cell oxidative stress impairs oxygen delivery and induces red blood cell aging.
Front Physiol
June 2014
Molecular Dynamics Section, Laboratory of Molecular Gerontology, National Institute on Aging Baltimore, MD, USA.
Red Blood Cells (RBCs) need to deform and squeeze through narrow capillaries. Decreased deformability of RBCs is, therefore, one of the factors that can contribute to the elimination of aged or damaged RBCs from the circulation. This process can also cause impaired oxygen delivery, which contributes to the pathology of a number of diseases.
View Article and Find Full Text PDFThe role of peroxyredoxin in the antioxidant system of respiratory organs.
Dokl Biophys
April 2001
Institute of Cell Biophysics, Russian Academy of Sciences, pr. Nauki 5, Pushchino, Moscow Oblast, 142292 Russia.
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