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An oncoprotein CREPT functions as a co-factor in MYC-driven transformation and tumor growth.
J Biol Chem
November 2024
State Key Laboratory of Membrane Biology, School of Medicine, Tsinghua University, Beijing, China. Electronic address:
Understanding the mechanisms behind MYC-driven oncogenic transformation could pave the way for identifying novel drug targets. This study explored the role of CREPT in MYC-induced malignancy by generating MYC-transformed mouse embryonic fibroblasts (MEFs) with conditional CREPT deletion. Our results demonstrated that the loss of CREPT significantly impaired MYC-induced colony formation and cell proliferation, indicating that CREPT is essential for the malignant transformation of MEFs.
View Article and Find Full Text PDFThe small membrane protein CcoS is involved in cofactor insertion into the cbb-type cytochrome c oxidase.
Biochim Biophys Acta Bioenerg
January 2025
Institut für Biochemie und Molekularbiologie, ZBMZ, Faculty of Medicine, Albert-Ludwigs-Universität Freiburg, Freiburg, Germany. Electronic address:
Respiratory complexes, such as cytochrome oxidases, are cofactor-containing multi-subunit protein complexes that are critically important for energy metabolism in all domains of life. Their intricate assembly strictly depends on accessory proteins, which coordinate subunit associations and cofactor deliveries. The small membrane protein CcoS was previously identified as an essential assembly factor to produce an active cbb-type cytochrome oxidase (cbb-Cox) in Rhodobacter capsulatus, but its function remained unknown.
View Article and Find Full Text PDFAAA+ ATPase chaperone p97/VCP governs basal pexophagy.
Nat Commun
October 2024
Department of Biomolecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University (TMDU) (Medical Research Laboratory, Institute of Integrated Research, Institute of Science Tokyo), 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.
Peroxisomes are organelles that are central to lipid metabolism and chemical detoxification. Despite advances in our understanding of peroxisome biogenesis, the mechanisms maintaining peroxisomal membrane proteins remain to be fully elucidated. We show here that mammalian FAF2/UBXD8, a membrane-associated cofactor of p97/VCP, maintains peroxisomal homeostasis by modulating the turnover of peroxisomal membrane proteins such as PMP70.
View Article and Find Full Text PDFProlonged xenokidney graft survival in sensitized NHP recipients by expression of multiple human transgenes in a triple knockout pig.
Sci Transl Med
June 2024
Duke Transplant Center, Duke University School of Medicine, Durham, NC 27710, USA.
Genetic modification of porcine donors, combined with optimized immunosuppression, has been shown to improve outcomes of experimental xenotransplant. However, little is known about outcomes in sensitized recipients, a population that could potentially benefit the most from the clinical implementation of xenotransplantation. Here, five highly allosensitized rhesus macaques received a porcine kidney from (α1,3-galactosyltransferase) knockout pigs expressing the human transgene (1KO.
View Article and Find Full Text PDFChronic spindle assembly checkpoint activation causes myelosuppression and gastrointestinal atrophy.
EMBO Rep
June 2024
Institute for Developmental Immunology, Biocenter, Medical University of Innsbruck, Innsbruck, Austria.
Interference with microtubule dynamics in mitosis activates the spindle assembly checkpoint (SAC) to prevent chromosome segregation errors. The SAC induces mitotic arrest by inhibiting the anaphase-promoting complex (APC) via the mitotic checkpoint complex (MCC). The MCC component MAD2 neutralizes the critical APC cofactor, CDC20, preventing exit from mitosis.
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