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Contemporary Perspectives in Critical Care of Neuroleptic Malignant Syndrome.
Neurocrit Care
January 2025
Department of Neurology, Mayo Clinic Rochester, Rochester, MN, USA.
Background: Neuroleptic malignant syndrome (NMS) is a psychiatric-neurologic emergency that may require intensive care management. There is a paucity of information about NMS as a critical illness. We reviewed the Mayo Clinic experience.
View Article and Find Full Text PDFAcute Torticollis Reaction Following Metoclopramide Use in a Pediatric Patient: A Comprehensive Case Report and Appraisal of Current Knowledge.
Int Med Case Rep J
December 2024
Faculty of Medicine, Mogadishu University, Mogadishu, Somalia.
Dopamine receptor antagonists like metoclopramide are frequently used in a variety of clinical contexts to treat gastrointestinal disorders and control nausea and vomiting. However, it is associated with a high incidence of extrapyramidal side effects (EPS) in children, including dystonic movements and torticollis. This is the instance of a 9-year-old girl who developed abnormal movements of the neck and tongue, along with torticollis, within 48 hours of receiving intravenous metoclopramide for gastroenteritis.
View Article and Find Full Text PDFTriphasic Bone Scintigraphy Is Not Useful in Diagnosis and May Delay Surgical Treatment of CRPS of the Hand.
J Hand Surg Asian Pac Vol
November 2024
Hand Surgery, Private Practice, Madrid, Spain.
Triphasic bone scintigraphy (TPBS) is often used to diagnose complex regional pain syndrome (CRPS). The primary aim of this study is to determine if the diagnosis of CRPS in patients with a positive TPBS (TPBS +ve) is accurate. A secondary aim is to determine if there was delay in treatment of patients who underwent TPBS compared to those who did not have a TPBS.
View Article and Find Full Text PDFA Rare Occurrence of Delayed Olanzapine-Induced Oculogyric Crisis in a Postpartum Patient: A Case Report.
Cureus
September 2024
Psychiatry, Al Amal Psychiatric Hospital, Emirates Health Services, Dubai, ARE.
Oculogyric crisis (OGC) is an acute dystonic reaction characterized by involuntary upward deviation of the eyes, often linked to the use of antipsychotic medications. While commonly associated with first-generation antipsychotics (FGAs) due to their higher propensity to cause extrapyramidal symptoms (EPS), OGC remains a rare but documented occurrence with second-generation antipsychotics (SGAs). SGAs, including olanzapine, are generally preferred in clinical practice due to their reduced risk of EPS; however, they are not completely devoid of such adverse effects.
View Article and Find Full Text PDFDysphagia and Muscle Weakness Secondary to Botulinum Toxin Type A Treatment of Cervical Dystonia: A Drug Class Analysis of Prescribing Information.
Toxins (Basel)
October 2024
Revance Therapeutics, Nashville, TN 37203, USA.
Article Synopsis
- The primary treatment for cervical dystonia (CD) symptoms involves botulinum toxin type A (BoNTA) injections, but comparing the safety of different BoNTAs is challenging due to non-interchangeable activity units.
- A study examined the relationship between the incidence of dysphagia and muscle weakness—key adverse effects—across BoNTAs approved in the US, finding that adverse drug reaction rates correlate strongly with the core neurotoxin content.
- DaxibotulinumtoxinA (DAXI) showed a lower core neurotoxin amount compared to conventional BoNTAs, indicating a potentially better safety profile and fewer adverse effects for patients with CD.
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