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A customizable multiplex protein microarray for antibody testing and its application for tick-borne and other infectious diseases.
Sci Rep
January 2025
Vibrant Sciences LLC., San Carlos, CA, USA.
Tick-borne infections are the most common vector-borne diseases in the USA. Ticks harbor and transmit several infections with Lyme disease being the most common tickborne infection in the US and Europe. Lack of awareness about tick populations, specific diagnostic tests, and overlapping signs and symptoms of tick-borne infections can often lead to misdiagnosis affecting treatment and the prevalence data reported especially for non-Lyme tick-borne infections.
View Article and Find Full Text PDFUnlabelled: The spirochete causes Lyme disease. In some patients, an excessive, dysregulated proinflammatory immune response can develop in joints leading to persistent arthritis. In such patients, persistence of antigenic peptidoglycan (PG ) fragments within joint tissues may contribute to the immunopatho-genesis, even after appropriate antibiotic treatment.
View Article and Find Full Text PDFUnlabelled: How tick-borne pathogens interact with their hosts has been primarily studied in vertebrates where disease is observed. Comparatively less is known about pathogen interactions within the tick. Here, we report that ticks infected with either (causative agent of anaplasmosis) or (causative agent of Lyme disease) show activation of the ATF6 branch of the unfolded protein response (UPR).
View Article and Find Full Text PDFMolecular prevalence of , and in dogs and associated ticks in Egypt: Emerging One Health challenging zoonoses.
Vet World
November 2024
Department of Microbiology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.
Background And Aim: Tick-borne pathogens pose a significant problem in canines, other animals, and humans worldwide. This study aimed to estimate the prevalence of , and in dogs and associated ticks in Egypt.
Materials And Methods: Blood samples from 110 tick-infested dogs and 550 whole ticks (divided into 110 pools) were collected and tested for the targeted pathogens using polymerase chain reaction (PCR).
There Goes the Neighbourhood-A Multi-City Study Reveals Ticks and Tick-Borne Pathogens Commonly Occupy Urban Green Spaces.
Zoonoses Public Health
January 2025
Department of Biology, University of Turku, Turku, Finland.
Introduction: Humans acquire tick-borne pathogens (TBPs) from infected ticks contacted during outdoor activities. Outdoor activity is at its highest in urban green spaces, where the presence of tick populations has increasingly been observed. Consequently, more insight into factors influencing the presence of ticks therein is needed.
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