N6-Naphthalenemethyl-2'-methoxybenzamido-beta-NAD+, a derivative of a low micromolar first-generation inhibitor of trypanosomal glyceraldehyde phosphate dehydrogenase (GAPDH), was synthesized, taking advantage of methodology for the selective phosphitylation of nucleosides. The compound was found to be a poor alternate cosubstrate for GAPDH, but an extremely potent inhibitor. Although intended for use in crystallization trials, the analogue presents possibilities for further drug design.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0960-894x(00)00608-9 | DOI Listing |
Publication Analysis
Top Keywords
inhibitor trypanosomal
8
disubstituted nad+
4
nad+ analogue
4
analogue nanomolar
4
nanomolar inhibitor
4
trypanosomal glyceraldehyde-3-phosphate
4
glyceraldehyde-3-phosphate dehydrogenase
4
dehydrogenase n6-naphthalenemethyl-2'-methoxybenzamido-beta-nad+
4
n6-naphthalenemethyl-2'-methoxybenzamido-beta-nad+ derivative
4
derivative low
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!