AI Article Synopsis
- A library of new cyclic alkoxyketones was created using solid-phase synthesis.
- These compounds demonstrated significant inhibitory effects on the enzyme cathepsin K, which is a type of cysteine protease.
- This research suggests potential applications for these alkoxyketones in therapies targeting diseases involving cathepsin K.
Article Abstract
Using solid-phase synthesis, a library of novel cyclic alkoxyketones has been constructed which show strong inhibitory activity against the cysteine protease, cathepsin K (EC 3.4.22.38).
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| http://dx.doi.org/10.1016/s0960-894x(00)00626-0 | DOI Listing |
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