Hydrogen clearance, polarographic, and electric impedance measurements on conscious rabbits with electrodes implanted into brain cortex, thalamus, and hypothalamus were used to study the state of hemodynamics, oxygen and water--electrolyte balance on a model of the zero-gravity-induced cerebrovascular disorders. The preliminary administration of mildronate (10 mg/kg, p.o.) reduced the hemodynamics disorder and optimized the oxygen balance more significantly than did riboxin (5 mg/kg). Both drugs markedly decreased the level of edematous phenomena in the brain. The antihypoxant and antiedematous effects of mildronate and riboxin increased upon their combined administration.
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