The paper presents the results of administration of alpha-dihydroergocryptine preparation (vasobral) to parkinsonic patients. It was prescribed to 20 patients with parkinsonism together with the specific therapy. Clinical state as well as the level of anxiety and depression was estimated using standard scales both before and after treatment. A high efficiency of vasobral was found as regards such symptoms as disorders of memory, headache, vertigo, a noise in ears and head, asthenic state. In some patients functional activity increased, in 4 patients a dose of dopaminergic preparations was successfully decreased by 25%. An important aspect of vasobral activity was also a decrease of anxious-depressive symptoms. A conclusion was made about efficiency of vasobral in combined treatment of parkinsonic patients.
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Porto Biomed J
August 2021
Faculty of Health Sciences, Fernando Pessoa University.
Background: External stimuli can improve gait performance in Parkinsons Disease (PD): auditory stimuli can increase velocity and visual stimuli may act at step length.
Objective: To systematize the scientific evidence about the effects of auditory or visual stimuli on gait in patients with PD.
Methods: From January 2016 to December 2018, a systematic literature research was conducted in the PubMed/Medline and Web of Science databases.
Curr Pharm Des
September 2019
GALLY International Biomedical Research Consulting LLC., 7733 Louis Pasteur Drive, #330, San Antonio, TX, 78229, United States.
The use of systematic approach for the analysis of mechanism of action of drugs at different levels of biological organization of organisms is an important task in experimental and clinical pharmacology for drug designing and increasing the efficacy and safety of drugs. The analysis of published data on pharmacological effects of psychotropic drugs possessing immunomodulatory and/or antiviral properties have shown a correlation between central effects of examined drugs associated with the impact on the processes of neurogenesis of adult brain and survival of neurons, and their ability to alter levels of key proinflammatory cytokines. The changes that occur as a result of the influence of pharmacological agents at one of the systems should inevitably lead to the functional reorganization at another.
View Article and Find Full Text PDFCognitive evoked potential P300 in response to visual verbal and non-verbal stimuli was examined in 40 patients with idiopathic Parkinson's disease (PD) without cognitive impairment and 8 age- and sex matched normal controls. All the patients were subjected to clinical and neuropsychological evaluation. The influence of patient's age, duration, type and severity of the disease, debut's lateralization and anti-parkinsonic therapy efficacy on P300 was evaluated.
View Article and Find Full Text PDFZh Nevrol Psikhiatr Im S S Korsakova
April 2001
The paper presents the results of administration of alpha-dihydroergocryptine preparation (vasobral) to parkinsonic patients. It was prescribed to 20 patients with parkinsonism together with the specific therapy. Clinical state as well as the level of anxiety and depression was estimated using standard scales both before and after treatment.
View Article and Find Full Text PDFPsychol Med
May 1996
Department of Psychiatry, University of Frankfurt, Germany.
We investigated serum creatine phosphokinase (CPK) and associated parkinsonic (SEPS) and dyskinetic (AIMS) movements in 32 hospital admitted acute catatonic patients. Thirty-two (N = 24 without neuroleptics on admission) catatonic patients were compared with 32 non-catatonic dyskinetic psychiatric patients, 32 non-catatonic non-dyskinetic psychiatric patients and 32 healthy controls. CPK was significantly higher (P = 0.
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