This article considers an analytic strategy for measuring and modeling child and adolescent problem behaviors. The strategy embeds an item response model within a hierarchical model to define an interval scale for the outcomes, to assess dimensionality, and to study how individual and contextual factors relate to multiple dimensions of problem behaviors. To illustrate, the authors analyze data from the primary caregiver ratings of 2,177 children aged 9-15 in 79 urban neighborhoods on externalizing behavior problems using the Child Behavior Checklist 4-18 (T. M. Achenbach, 1991a). Two subscales, Aggression and Delinquency, are highly correlated, and yet unidimensionality must be rejected because these subscales have different associations with key theoretically related covariates.
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http://dx.doi.org/10.1037/1082-989x.5.4.477 | DOI Listing |
J Pain Res
January 2025
Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, People's Republic of China.
Purpose: To develop a training program on cancer pain management for pharmacists and to evaluate the effectiveness of the training.
Methods: The program developed a well-structured curriculum and subsequent evaluation of training effectiveness, guided by the Kirkpatrick four-tier evaluation model, including reaction, learning, behavior, and results. The training approach incorporated mentoring, study groups, and problem-based learning to create an immersive and impactful learning experience.
Multiplexed Immunofluorescence (MxIF) enables detailed immune cell phenotyping, providing critical insights into cell behavior within the tumor immune microenvironment (TIME). However, signal integrity can be compromised due to the complex cyclic staining processes inherent to MxIF. Hematoxylin and Eosin (H&E) staining, on the other hand, offers complementary information through its depiction of cell morphology and texture patterns and is often visually cross-referenced with MxIF in clinical settings.
View Article and Find Full Text PDFMater Today Bio
February 2025
Department of Biochemistry and Molecular Pharmacology. Istituto di Ricerche Farmacologiche Mario Negri, IRCCS, Via Mario Negri, 2, Milan, Italy.
Targeting is the most challenging problem to solve for drug delivery systems. Despite the use of targeting units such as antibodies, peptides and proteins to increase their penetration in tumors the amount of therapeutics that reach the target is very small, even with the use of nanoparticles (NPs). Nature has solved the selectivity problem using a combination of proteins and lipids that are exposed on the cell membranes and are able to recognize specific tissues as demonstrated by cancer metastasis.
View Article and Find Full Text PDFDiabetes Metab Syndr Obes
January 2025
Department of Nursing, Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, People's Republic of China.
Background: This study sought to explore the interrelationship between diabetes-related distress, patient evaluations of chronic illness management, and self-management practices among older adults diagnosed with T2DM and associated chronic complications.
Methods: This was a cross-sectional study including 264 older adults with T2DM in Shanghai, China. Chinese version of Problem Areas in Diabetes Scale (PAID-C), Patient Assessment of Chronic Illness Care (PACIC) and Diabetes Self-Management Behaviour for Older (DSMB-O) were employed.
J Res Adolesc
March 2025
Department of Clinical Psychology, Institute of Psychology, Leiden University, Leiden, The Netherlands.
Autonomy support (AS) and psychological control (PC) are important parenting behaviors in adolescence, with low AS and high PC relating to adolescent depression. Studies on observed levels of AS and PC in a clinical sample are lacking. The current study aimed to (1) develop a reliable coding system for parental AS and PC in parent-adolescent interactions and gain insights into its ecological validity in a healthy control (HC) sample, and (2) disentangle observed and adolescent-perceived parenting behaviors in relation to adolescent depression.
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