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http://dx.doi.org/10.1111/j.1749-6632.2000.tb06986.x | DOI Listing |
Front Immunol
December 2024
Institute of Forensic Medicine and Laboratory Medicine, Jining Medical University, Jining, China.
The defense mechanisms of the vertebrate brain against infections are at the forefront of immunological studies. Unlike other body parts, the brain not only fends off pathogenic infections but also minimizes the risk of self-damage from immune cell induced inflammation. Some neuropeptides produced by either nerve or immune cells share remarkable similarities with antimicrobial peptides (AMPs) in terms of size, structure, amino acid composition, amphiphilicity, and net cationic charge.
View Article and Find Full Text PDFPeptides
January 2025
Programa Multicêntrico de Pós-Graduação em Ciências Fisiológicas, Universidade Estadual de Londrina, Londrina, PR, Brazil; Programa de Pós-Graduação em Ciências Fisiológicas, Universidade Estadual de Londrina, Londrina, PR, Brazil; Laboratório de Fisiologia Neuroendócrina e Metabolismo, Departamento de Ciências Fisiológicas, Universidade Estadual de Londrina, Londrina, PR, Brazil. Electronic address:
Neurologia (Engl Ed)
June 2023
Servicio de Neurología, Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain. Electronic address:
J Headache Pain
October 2024
Dompé Farmaceutici SpA, Via Santa Lucia 6, 20122, Milano, Italy.
Int J Mol Sci
August 2024
School of Molecular Bioscience, University of Sydney, Sydney, NSW 2006, Australia.
Inflammation with expression of interleukin 6 (IL-6) in the central nervous system (CNS) occurs in several neurodegenerative/neuroinflammatory conditions and may cause neurochemical changes to endogenous neuroprotective systems. Pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal polypeptide (VIP) are two neuropeptides with well-established protective and anti-inflammatory properties. Yet, whether PACAP and VIP levels are altered in mice with CNS-restricted, astrocyte-targeted production of IL-6 (GFAP-IL6) remains unknown.
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