The activity of CPK was proved in cultivated cells from amniotic fluid cells, thymus, spleen, pericardium, umbilical cord, skin and muscle. The activity in these strains did not significantly differ. The average value is 224 plus or minus 68 i.u. CPK/mg N. No differences of activity were disclosed between embryonal, foetal and children cultures. The activity of CPK in post mortem cultures was not altered. The relationship between collagen synthesis and CPK activity is suggested. The evidence of CPK activity in amniotic fluid cells corresponding to the activity in other foetal cultures and the whole sample under investigation opens the way to the prenatal investigation of pathophysiology and inborn errors of the metabolism of this enzyme.
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